Tissue Eng Regen Med.
2018 Jun;15(3):249-261. 10.1007/s13770-017-0112-8.
Stem Cell Tracing Through MR Molecular Imaging
- Affiliations
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- 1School of Medicine, Jiroft University of Medical Sciences, Jiroft 8813833435, Iran.
- 2Department of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan 3715835155, Iran.
- 3Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
- 4Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.
- 5Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran 1417613151, Iran.
- 6Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 6135715794, Iran.
- 7Department of Chemistry, Faculty of Science, Islamic Azad University, Arak 3836119131, Iran.
- 8Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Science, Kermanshah 6714869914, Iran. masoudnajafi67@yahoo.com
- 9Department of Molecular Medicine, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 194193311, Iran. e_motevaseli@tums.ac.ir
- KMID: 2411874
- DOI: http://doi.org/10.1007/s13770-017-0112-8
Abstract
- Stem cell therapy opens a new window in medicine to overcome several diseases that remain incurable. It appears such diseases as cardiovascular disorders, brain injury, multiple sclerosis, urinary system diseases, cartilage lesions and diabetes are curable with stem cell transplantation. However, some questions related to stem cell therapy have remained unanswered. Stem cell imaging allows approval of appropriated strategies such as selection of the type and dose of stem cell, and also mode of cell delivery before being tested in clinical trials. MRI as a non-invasive imaging modality provides proper conditions for this aim. So far, different contrast agents such as superparamagnetic or paramagnetic nanoparticles, ultrasmall superparamagnetic nanoparticles, fluorine, gadolinium and some types of reporter genes have been used for imaging of stem cells. The core subject of these studies is to investigate the survival and differentiation of stem cells, contrast agent's toxicity and long term following of transplanted cells. The promising results of in vivo and some clinical trial studies may raise hope for clinical stem cells imaging with MRI.
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