Ann Pediatr Endocrinol Metab.  2018 Mar;23(1):38-42. 10.6065/apem.2018.23.1.38.

The relationship between subclinical hypothyroidism and serum levels of uric acid and creatinine in children aged 2–14 years

• Sayari S
• Molaei Z
• Torabi Z

• KMID: 2409789
• DOI: http://doi.org/10.6065/apem.2018.23.1.38

Abstract

PURPOSE
Hypothyroidism is a clinical syndrome that can lead to elevated levels of serum creatinine and uric acid by causing impaired renal function. Although many studies have been carried out on the relationship between overt hypothyroidism and renal function, few studies have been conducted on subclinical hypothyroidism and renal function, especially in pediatric patients. For this reason, we studied this issue in children, so as to provide a background for more useful research and future education.
METHODS
This case-control study was performed on 107 children aged 2-14 years, 56 children with subclinical hypothyroidism in the case group, and 51 healthy children in the control group presenting to Ayatollah Mousavi Hospital in Zanjan and private clinics of Zanjan city. Thyroid stimulating hormone, triiodothyronine, thyroxine, creatinine, and uric acid were measured in both groups of children after obtaining the necessary criteria for entering the study.
RESULTS
Compared to the control group, subjects with subclinical hypothyroidism had higher levels of creatinine (P=0.003), while serum uric acid levels in subclinical hypothyroid children was not significantly different from those in the control group (P=0.200).
CONCLUSIONS
In subclinical hypothyroidism in children, creatinine was higher than in euthyroid patients, but uric acid was not different.

Keyword

Uric acid; Creatinine; Hypothyroidism

MeSH Terms

Case-Control Studies
Child*
Creatinine*
Education
Humans
Hypothyroidism*
Thyrotropin
Thyroxine
Triiodothyronine
Uric Acid*
Creatinine
Thyrotropin
Thyroxine
Triiodothyronine
Uric Acid

Figure

• 

  Fig. 1. (A) Box and whisker plot showing comparison of creatinine between case and control group. The boxes contain 50% of values between the 25th and 75th percentiles; the whiskers indicate the highest and lowest values. The horizontal line inside each box represents the median. (B) Box and whisker plot showing comparison of uric acid between case and control group. The boxes contain 50% of values between the 25th and 75th percentiles; the whiskers indicate the highest and lowest values. The horizontal line inside each box represents the median.

Reference

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