Nat Prod Sci.
2015 Mar;21(1):49-53. 10.0000/nps.2015.21.1.49.
Anti-Helicobacter pylori Compounds from Maackia amurensis
- Affiliations
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- 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju 660-701, Korea. amj5812@gnu.ac.kr
- 2Department of Microbiology, School of Medicine and Research Institute of Life Sciences, Gyeongsang National University, Jinju 660-751, Korea.
- 3Cho-A Pharmaceutical Company, Seoul 150-902, Korea.
- 4College of Pharmacy, Chungbuk National University, Cheongju 361-763, Korea.
- KMID: 2409599
- DOI: http://doi.org/10.0000/nps.2015.21.1.49
Abstract
- Eight isoflavonoid compounds were isolated from the EtOAc fraction of Maackia amurensis which had shown the highest anti-Helicobacter pylori activity among the fractions, using medium pressure liquid chromatography and recrystallization. Based on the spectroscopic data including 1H-NMR, 13C-NMR, HMBC and MS data, the chemical structures of the isolates were determined to be (-)-medicarpin (1), afromosin (2), formononetin (3), tectorigenin (4), prunetin (5), wistin (6), tectoridin (7) and ononin (8). Anti-H. pylori activity of each compound was evaluated with broth dilution assay. As a result, (-)-medicarpin (1), tectorigenin (4) and wistin (6) showed anti-H. pylori activity. (-)-Medicarpin (1) exhibited the most potent growth inhibitory activity against H. pylori with the minimal inhibitory concentration (MIC)90 of 25 microM, and tectorigenin (4) with MIC90 of 100 microM ranked the second. This is the first study to show the anti-H. pylori activity of M. amurensis, and it is suggested that the stem bark of M. amurensis or the EtOAc fraction or the isolated compounds can be a new natural source for the treatment of H. pylori infection.
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