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Changes in Seroprevalence of Helicobacter pylori Infection over 20 Years in Jinju, Korea, from Newborns to the Elderly

Park JS, Jun JS, Ryu EY, Yeom JS, Park ES, Seo JH, Lim JY, Park CH, Woo HO, Baik SC, Lee WK, Cho MJ, Rhee KH, Youn HS

Background: The objective of this study was to examine changes in the prevalence of cytotoxic-associated gene A (CagA) positive Helicobacter pylori infection in Jinju, Korea, over the last 20 years. Methods:...
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Proteome Analysis of Alkylhydroxide Peroxidase-Deficient Isogenic Mutant of Helicobacter pylori 26695

Lee WK, Baik SC, Shin MK, Jung M, Park JS, Ha JH, Lee DH, Kim MJ, Shin JI, Kang HL

In order to investigate the antioxidant effect of alkylhydroxide peroxidase (ahpC) of Helicobacter pylori (H. pylori) 26695, an ahpC-deficient mutant (H. pylori 26695 ahpC::cat) was generated. ahpC-deficient mutant was grown...
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Characterization of Specific IgA Response to Antigenic Determinants of Helicobacter pylori Urease Encoded by ureA and ureB in Children

Shin MK, Jun JS, Kwon SW, Lee DH, Ha JH, Park JS, Song DH, Jung MH, Kang HL, Baik SC, Park JS, Youn HS, Cho MJ, Seo JH, Lee WK

Helicobacter pylori (H. pylori), a causative agent of chronic gastritis and gastric cancer, has several virulent factors for own survival and progression toward gastric diseases in human stomach. Of those,...
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Gene Expression Profiles of Th1-type Chemokines in Whole Blood of Mycobacterium avium subsp. paratuberculosis-Infected Cattle

Shin MK, Park HE, Park HT, Jung M, Kang HL, Baik SC, Lee WK, Jung YH, Yoo HS

Johne's disease (JD) is a chronic, debilitating disease of ruminants including cows, and is caused by Mycobacterium avium subsp. paratuberculosis (MAP). MAP is not only important in animal husbandry, but...
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Helicobacter pylori Antigens Inducing Early Immune Response in Infants

Seo JH, Youn JH, Kim EA, Jun JS, Park JS, Yeom JS, Lim JY, Woo HO, Youn HS, Ko GH, Park JS, Baik SC, Lee WK, Cho MJ, Rhee KH

To identify the Helicobacter pylori antigens operating during early infection in sera from infected infants using proteomics and immunoblot analysis. Two-dimensional (2D) large and small gel electrophoresis was performed using...
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Correlations between the CagA Antigen and Serum Levels of Anti-Helicobacter pylori IgG and IgA in Children

Seo JH, Lim CW, Park JS, Yeom JS, Lim JY, Jun JS, Woo HO, Youn HS, Baik SC, Lee WK, Cho MJ, Rhee KH

We tested correlations between anti-Helicobacter pylori IgG and IgA levels and the urease test, anti-CagA protein antibody, degree of gastritis, and age. In total, 509 children (0-15 years) were enrolled....
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Anti-Helicobacter pylori Compounds from Maackia amurensis

Park WS, Bae JY, Kim HJ, Kim MG, Lee WK, Kang HL, Baik SC, Lim KM, Lee MK, Ahn MJ

Eight isoflavonoid compounds were isolated from the EtOAc fraction of Maackia amurensis which had shown the highest anti-Helicobacter pylori activity among the fractions, using medium pressure liquid chromatography and recrystallization....
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Association between Gastric pH and Helicobacter pylori Infection in Children

Seo JH, Park HK, Park JS, Yeom JS, Lim JY, Park CH, Woo HO, Youn HS, Jun JS, Ko GH, Baik SC, Lee WK, Cho MJ, Rhee KH

PURPOSE: To assess gastric pH and its relationship with urease-test positivity and histological findings in children with Helicobacter pylori infection. METHODS: Fasting gastric juices and endoscopic antral biopsy specimens were collected...
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Helicobacter pylori Infection and Intestinal Metaplasia among Healthy Adolescents

Park JS, Rhie K, Seo JH, Ryu EY, Kim HJ, Kim HJ, Lim JY, Woo HO, Baik SC, Lee WK, Cho MJ, Rhee KH, Ko GH, Youn HS

BACKGROUND/AIMS: The purpose of our study was to investigate the change in incidence of intestinal metaplasia (IM) in healthy, young adults over 10 years. MATERIALS AND METHODS: Urease test and histopathology...
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Proteome Analysis of a Catalase-deficient Isogenic Mutant of Helicobacter pylori 26695

Kang HL, Lee SG, Park JS, Song JY, Cho MJ, Baik SC, Youn HS, Seo JH, Rhee KH, Lee WK

Helicobacter pylori, a gram-negative bacterium, is a causative agent of gastroduodenal diseases of human. Human immune system produces harmful reactive oxygen species to kill this bacterium that locates the microaerophilic...
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Correlation between Positive Rate and Number of Biopsy Samples on Urease Test in Childhood Helicobacter pylori Infection

Seo JH, Park JS, Yeom JS, Lim JY, Park CH, Woo HO, Baik SC, Lee WK, Cho MJ, Rhee KH, Youn HS

To identify the correlation between the number of gastric biopsy samples and the positive rate, we compared the results of urease test using one and three biopsy samples from each...
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Helicobacter pylori Infection and Duodenal Gastric Metaplasia in Healthy Young Adults

Seo JH, Do HJ, Park CH, Woo HO, Youn HS, Ko GH, Baik SC, Lee WK, Cho MJ, Rhee KH, Lee JH

BACKGROUND/AIMS: Duodenal ulcers occur relatively frequently in adolescents, like in adults, and may relate to Helicobacter pylori infection and duodenal gastric metaplasia (DGM). This study investigated the association between H....
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Influencing Factors to Results of the Urease Test: Age, Sampling Site, Histopathologic Findings, and Density of Helicobacter pylori

Seo JH, Youn HS, Park JJ, Yeom JS, Park JS, Jun JS, Lim JY, Park CH, Woo HO, Ko GH, Baik SC, Lee WK, Cho MJ, Rhee KH

PURPOSE: We investigated the positivity rate and the time period to the positive color change of the urease test in children and adults and assessed the correlation of the urease...
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Comparison of Gene Expression Patterns between Helicobacter pylor 26695 and its Superoxide Dismutase Isogenic Mutant

Cho MJ, Lee SG, Lee KH, Song JY, Lee WK, Baik SC, Rhee KH, Youn HS, Seo JH, Kang HL

Helicobacter pylori, a causative agent of gastroduodenal diseases, is a Gram-negative microaerophilic bacterium. Although H. pylori locates in the microaerophilic mucous layer, the bacteria would come into contact harmful reactive...
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Gastric Autoantigenic Proteins in Helicobacter Pylori Infection

Park JS, Lee SJ, Kim TH, Yeom J, Park ES, Seo JH, Jun JS, Lim JY, Park CH, Woo HO, Youn HS, Ko GH, Kang HL, Baik SC, Lee WK, Cho MJ, Rhee KH

PURPOSE: This study tried to identify novel gastric autoimmune antigens that might be involved in aggravating the atrophic gastritis among patients with Helicobacter pylori infection using two-dimensional immunoblotting analysis. MATERIALS AND...
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Changes in Anti-Group A Rotavirus Antibody Seroprevalence and Levels in the Western Gyeongnam Province of Korea Over 16 Years

Seo JH, Park JJ, Lim JY, Jun JS, Park CH, Woo HO, Youn HS, Kwon YC, Kang HL, Baik SC, Lee WK, Cho MJ, Rhee KH, Kim W

To observe how anti-group A rotavirus antibody seropositivity rates and levels have changed in the western region of Gyeongnam Province, 2,030 serum samples collected at four collection periods (1989-1990, 1994-1995,...
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Proteomic Analysis of Thiol-active Proteins of Helicobacter pylori 26695

Park JW, Song JY, Hwang HR, Park HJ, Youn HS, Seo JH, Kang HL, Lee KH, Baik SC, Lee WK, Cho MJ, Rhee KH

Helicobacter pylori are a capnophilic bacterium, which colonize gastric mucosa and are resistant to acidic and oxidative damage. Thiol-active proteins subserve redox functions in tolerating oxidative stress and environmental toxicants,...
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Comparison of Four Commercial ELISA Kits and In-House Immunoblotting for Diagnosis of Helicobacter pylori Infection

Jeong HL, Jung YS, Jun JS, Yeom JS, Park JS, Seo JH, Lim JY, Park CH, Woo HO, Youn HS, Ko GH, Baik SC, Lee WK, Cho MJ, Rhee KH

  • KMID: 2315325
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2012 Jun;15(2):85-90.
PURPOSE: Commercial enzyme-linked immunosorbent assay (ELISA) kits have been considered less reliable for children than for adults. The aim of this study was to compare four ELISA kits and in-house...
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Comparison of the Antibiotic Resistance of Helicobacter pylori Isolated in Jinju Over a 15-year Period

Seo JH, Koo SI, Youn HS, Jun JS, Lim JY, Park CH, Woo HO, Kang HL, Baik SC, Lee WK, Cho MJ, Rhee KH

The aims of this study were to investigate the changing pattern of Helicobacter pylori antibiotic resistance in Jinju over a 15-year period. H. pylori strains were isolated from 170 adults...
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Comparison of Proteome Components of Helicobacter pylori Before and After Mouse Passage

Lee KJ, Kim BR, Cho YA, Song YG, Song JY, Lee KH, Kang HL, Baik SC, Cho MJ, Rhee KH, Seo JH, Youn HS, Lee WK

The mouse model is alleged to be a useful tool for understanding of pathophysiological roles of Helicobacter pylori in the development of gastric disorders. However, it has been observed that...
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