Mycobiology.
2009 Jun;37(2):128-132.
Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
- Affiliations
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- 1Department of Biotechnology, Catholic University of Daegu, Gyungbuk 712-702, Korea. yangbk@cu.ac.kr
- 2Research Institute of Biomedical Engineering and Department of Medicine, Catholic University of Daegu, Daegu 705-718, Korea.
- 3Department of Surgery, College of Medicine, Konkuk University, Seoul 143-701, Korea.
- 4Dong-A University Hospital Clinical Research Center, Busan 602-715 and Oriental Medicine Industry Support Center, Daegu Technopark, Daegu 706-828, Korea.
- 5School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702-701, Korea.
- 6Zenitec Korea Co., Hyundai 41 Tower, Yangcheon-gu, Seoul 158-723, Korea.
Abstract
- The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 microg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
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