Ann Surg Treat Res.  2018 Jan;94(1):13-18. 10.4174/astr.2018.94.1.13.

Brain metastasis from colorectal cancer: a single center experience

• Kim DY
• Ryu CG
• Jung EJ
• Paik JH
• Hwang DY

• KMID: 2405334
• DOI: http://doi.org/10.4174/astr.2018.94.1.13

Abstract

PURPOSE
The detection rate of brain metastasis (BM) from colorectal cancer (CRC) is increasing. This study was designed to analyze the clinical features of BM and prognosis according to the therapeutic modalities.
METHODS
A total of 19 cases were collected in this study between November 2008 and December 2015. We reviewed the patients' demographic data and the clinical features of BM retrospectively and investigated their prognostic significance.
RESULTS
Nineteen patients included 8 male and 11 female patients. The median age at diagnosis of BM was 62.4 years (range, 32-83 years). The median interval between diagnosis of CRC and BM was 39 months (range, 0-98 months). Eighteen patients (94.7%) had extracranial metastasis at the diagnosis of BM. Lung was the most common site of extracranial metastasis in 14 patients (73.7%). Synchronous BMs were found at the diagnosis of primary CRC in 2 patients (10.5%). The location of primary CRC was the colon in 6 patients (31.6%) and the rectum in 13 patients (68.4%). At the diagnosis of BM, 10 patients (52.6%) had a solitary BM. The common neurologic symptoms were headache in 8 cases (42.1%) and ataxia in 6 cases (31.6%). The median survival after the diagnosis of BM was 3 months (range, 1-10 months). The patients who underwent surgery plus stereotactic radiosurgery (SRS) had an improved survival (range, 3-10 months) than the other patients (range, 1-6 months) (P = 0.016).
CONCLUSION
In patients with BM from CRC, surgical resection plus SRS might improve survival.

Keyword

Colorectal neoplasms; Brain; Neoplasm metastasis; Radiosurgeries; Prognosis

MeSH Terms

Ataxia
Brain*
Colon
Colorectal Neoplasms*
Diagnosis
Female
Headache
Humans
Lung
Male
Neoplasm Metastasis*
Neurologic Manifestations
Prognosis
Radiosurgery
Rectum
Retrospective Studies

Figure

• 

  Fig. 1 Kaplan-Meier survival curves for survival after the diagnosis of brain metastasis (BM) according to the treatment(P = 0.005).

• 

  Fig. 2 Kaplan-Meier survival curves for survival after the diagnosis of brain metastasis (BM) according to the number of BMs (P = 0.027).

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