Immune Netw.
2018 Feb;18(1):e1. 10.4110/in.2018.18.e1.
Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis
- Affiliations
-
- 1Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. chhkim@med.umich.edu, chkim@purdue.edu
- 2Mary H. Weiser Food Allergy Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
- 3Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.
- KMID: 2404888
- DOI: http://doi.org/10.4110/in.2018.18.e1
Abstract
- Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Expression and Distribution Pattern of Retinoic Acid Receptors in the Nasal Mucosa
- Innate immunity in asthma
- Comparison of Radiation Adaptive Responses in Peripheral Lymphocytes of Patients Undergoing Tc-99m MDP and Tc-99m DTPA Scintigraphies
- Immunohistochemical Expression of Nuclear Retinoid Receptor and CREB(cAMP Response Element Binding Protein) in Lung Cancers
- Recent advance in primary immune deficiency disorders
