Immune Netw.  2018 Feb;18(1):e1. 10.4110/in.2018.18.e1.

Control of Innate and Adaptive Lymphocytes by the RAR-Retinoic Acid Axis

Affiliations
  • 1Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA. chhkim@med.umich.edu, chkim@purdue.edu
  • 2Mary H. Weiser Food Allergy Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
  • 3Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, IN 47907, USA.

Abstract

Lymphocytes, such as T cells, B cells, and innate lymphoid cells (ILCs), play central roles in regulating immune responses. Retinoic acids (RAs) are vitamin A metabolites, produced and metabolized by certain tissue cells and myeloid cells in a tissue-specific manner. It has been established that RAs induce gut-homing receptors on T cells, B cells, and ILCs. A mounting body of evidence indicates that RAs exert far-reaching effects on functional differentiation and fate of these lymphocytes. For example, RAs promote effector T cell maintenance, generation of induced gut-homing regulatory and effector T cell subsets, antibody production by B cells, and functional maturation of ILCs. Key functions of RAs in regulating major groups of innate and adaptive lymphocytes are highlighted in this article.

Keyword

Retinoic acid; T-cells; B-cells; NK cells; Innate lymphoid cells

MeSH Terms

Antibody Formation
B-Lymphocytes
Killer Cells, Natural
Lymphocytes*
Myeloid Cells
T-Lymphocyte Subsets
T-Lymphocytes
Tretinoin
Vitamin A
Tretinoin
Vitamin A
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