Mycobiology.  2017 Dec;45(4):426-429. 10.5941/MYCO.2017.45.4.426.

Azole Resistance Caused by Increased Drug Efflux in Candida glabrata Isolated from the Urinary Tract of a Dog with Diabetes Mellitus

• Kim M
• Lee H
• Hwang SY
• Lee I
• Jung WH

• KMID: 2401074
• DOI: http://doi.org/10.5941/MYCO.2017.45.4.426

Abstract

A yeast-like organism was isolated from a urine sample of a 6-year-old neutered male miniature poodle dog with urinary tract infection, diabetes ketoacidosis, and acute pancreatitis. We identified the yeast-like organism to be Candida glabrata and found that this fungus was highly resistant to azole antifungal drugs. To understand the mechanism of azole resistance in this isolate, the sequences and expression levels of the genes involved in drug resistance were analyzed. The results of our analysis showed that increased drug efflux, mediated by overexpression of ATP transporter genes CDR1 and PDH1, is the main cause of azole resistance of the C. glabrata isolated here.

Keyword

Azole resistance; Candida glabrata; Diabetes; Dog; Drug efflux; Urinary tract

MeSH Terms

Adenosine Triphosphate
Animals
Candida glabrata*
Candida*
Child
Danazol*
Diabetes Mellitus*
Dogs*
Drug Resistance
Fungi
Humans
Ketosis
Male
Pancreatitis
Urinary Tract Infections
Urinary Tract*
Adenosine Triphosphate
Danazol