Psychiatry Investig.
2017 Sep;14(5):703-707. 10.4306/pi.2017.14.5.703.
Evidence for Hypothalamus-Pituitary-Adrenal Axis and Immune Alterations at Prodrome of Psychosis in Males
- Affiliations
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- 1School of Medicine, Rural Clinical School, The University of Queensland, Toowoomab, Australia. epkarani@yahoo.com
- 2Psychiatric Department, General Military Hospital of Thessaloniki, Thessaloniki, Greece.
- 32nd Psychiatric Department, Aristotle University of Thessaloniki, Psychiatric Hospital of Thessaloniki, Thessaloniki, Greece.
- 4General Military Hospital of Athens, Athens, Greece.
- KMID: 2395497
- DOI: http://doi.org/10.4306/pi.2017.14.5.703
Abstract
- We aimed to investigate the inflammatory substrate in psychosis by evaluating both the Hypothalamus-Pituitary-Adrenal axis function and immune state at prodrome. This involved the recruitment of Ultra High Risk (UHR) of Psychosis subjects, Healthy Controls (HC) and patients with established Schizophrenia (CHRON). Serum cortisol at 3 different times throughout the day was measured. The Dexamethasone Suppression Test was performed plus 12 circulating cytokines were measured. The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients. In contrast the UHR differed only from the CHRON group regarding the endocrine parameters. In conclusion, IL-4 appears to play a key role at prodrome.
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