Psychiatry Investig.  2017 Sep;14(5):693-697. 10.4306/pi.2017.14.5.693.

Association between GABA3 Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

Affiliations
  • 1Environmental Health Center, Dankook Medical Hospital, Cheonan, Republic of Korea. paperose@dku.edu
  • 2Department of Preventive Medicine, College of Medicine, Dankook University, Cheonan, Republic of Korea.
  • 3Department of Biological Sciences, College of Natural Science, Dankook University, Cheonan, Republic of Korea.
  • 4Department of Psychology, College of Public Welfare, Dankook University, Cheonan, Republic of Korea.

Abstract


OBJECTIVE
Attention deficit hyperactivity disorder (ADHD) is common disorder of the school-age population. ADHD is familial and genetic studies estimate heritability at 80-90%. The aim of the present study was to investigate the association between the genetic type and alleles for gamma-aminobutyric acid receptor subunit beta-3 (GABA3) gene in Korean children with ADHD.
METHODS
The sample consisted of 180 ADHD children and 159 control children. We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 339 subjects, DNA was extracted from blood lymphocytes, and PCR was performed for GABA3 rs2081648, rs1426217 and rs981778 Polymorphism. Alleles and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of GABA3 gene polymorphism in the ADHD and control groups.
RESULTS
This study showed that there was a significant correlation among the frequencies of the rs2081648 (OR=0.71, 95% CI=0.51-0.98, p=0.040) of alleles of MAO, but the final conclusions are not definite. Follow up studies with larger patient or pure subgroups are expected.
CONCLUSION
These results suggested that GABA3 might be related to ADHD symptoms.

Keyword

ADHD; Polymorphism; GABA; Korean children

MeSH Terms

Alleles
Attention Deficit Disorder with Hyperactivity*
Child*
Diagnostic and Statistical Manual of Mental Disorders
DNA
Follow-Up Studies
gamma-Aminobutyric Acid
Genotype
Humans
Lymphocytes
Monoamine Oxidase
Parents
Polymerase Chain Reaction
Receptors, GABA
Weights and Measures
DNA
Monoamine Oxidase
Receptors, GABA
gamma-Aminobutyric Acid
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