Gut Liver.
2017 Nov;11(6):798-806. 10.5009/gnl16557.
The Effect of Intragastric Administration of Botulinum Toxin Type A on Reducing Adiposity in a Rat Model of Obesity Using Micro-CT and Histological Examinations
- Affiliations
-
- 1Digestive Disease Center, Department of Internal Medicine, Inha University School of Medicine, Incheon, Korea. inos@inha.ac.kr
- 2National Center of Efficacy Evaluation for the Development of Health Products Targeting Digestive Disorders (NCEED), Incheon, Korea.
- 3Bio R&D Center, Daewoong Pharmaceutical, Yongin, Korea.
- 4Utah-Inha DDS & Advanced Therapeutics Research Center, Incheon, Korea.
- KMID: 2395384
- DOI: http://doi.org/10.5009/gnl16557
Abstract
- BACKGROUND/AIMS
Botulinum toxin type A (BTX), a long-acting inhibitor of muscular contraction in both striated and smooth muscles, is responsible for gastric motility. The aim of this study was to investigate the effects of an endoscopic intragastric BTX injection on weight loss, body fat accumulation, and gastric emptying time.
METHODS
The BTX group consisted of 15 obese rats in which 20 U of BTX were injected into the gastric antrum. The saline group consisted of 15 obese rats injected with 20 U of saline, and the control group included 10 obese rats that did not receive a surgical intervention. The gastric emptying time, biochemical parameters, and body fat volume were evaluated using micro-computed tomography (micro-CT) and histologic evaluations.
RESULTS
The postoperative body weight of the BTX group was significantly lower than those of the other groups (p < 0.001) at 6 weeks after the operation. The gastric emptying time (156±54 minutes) was significantly delayed in the BTX group. The BTX group showed significantly lower lipid levels than the other groups. A reduction in body fat volume was observed in the BTX group using micro-CT and histological evaluations.
CONCLUSIONS
BTX application to the gastric antrum represents a potentially effective treatment for obesity and may help improve the lipid profile by increasing the gastric emptying time.
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