J Mov Disord.
2017 Sep;10(3):123-129. 10.14802/jmd.17048.
Sleepiness and Depression in Parkinson's Disease Patients Treated with Ropinirole and Levodopa
- Affiliations
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- 1Department of Neurology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.
- 2Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sjchung@amc.seoul.kr
- 3Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, Korea.
- 4Department of Neurology, Inje University College of Medicine, Busan, Korea.
- 5Department of Neurology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
- 6Department of Neurology, Yeungnam University Medical Center, Daegu, Korea.
- 7Department of Neurology Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- 8Department of Neurology, Soonchunhyang University Seoul Hospital, Soonchunhyang University School of Medicine, Seoul, Korea.
- 9Department of Neurology, Korea University College of Medicine, Korea University Guro Hospital, Seoul, Korea.
- 10Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.
- 11Department of Neurology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
- 12Department of Neurology, Yonsei University College of Medicine, Seoul, Korea. yhsohn62@yuhs.ac
- KMID: 2395008
- DOI: http://doi.org/10.14802/jmd.17048
Abstract
OBJECTIVE
We aimed to investigate the effect of ropinirole on excessive daytime sleepiness (EDS) and depression in Parkinson's disease (PD) with a large population.
METHODS
We conducted a cross-sectional observational study at nine hospitals in Korea between April 24, 2013, and April 22, 2015. We analyzed the demographic and clinical features, other medical history, history of antiparkinsonian medication within 6 months, Hoehn and Yahr stage (HY stage), Unified Parkinson's Disease Rating Scale (UPDRS) part II and III, Epworth Sleepiness Scale (ESS), and 30-item Geriatric Depression Scale (GDS-30).
RESULTS
Four-hundred-thirteen patients with PD (mean age: 65.2 ± 9.0 years; men: 227 patients) were analyzed. Multivariate logistic regression analysis showed that age at examination, UPDRS II, and GDS-30 were independent risk factors for EDS and that sex, UPDRS II, and ESS were independent risk factors for depression.
CONCLUSION
Our large group study did not find any significant associations of ropinirole with EDS and depression in Korean PD patients.
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