Tissue Eng Regen Med.  2017 Aug;14(4):327-332. 10.1007/s13770-017-0043-4.

Endothelial Progenitor Cells' Classification and Application in Neurological Diseases

• Yuan JJ
• Yang J
• Sun SL
• Zhang R
• Xu YM

• KMID: 2394967
• DOI: http://doi.org/10.1007/s13770-017-0043-4

Abstract

The therapeutic effects of endothelial progenitor cells (EPCs) on ischemic stroke have been extensively studied in recent years. However, the differences in early EPCs and endothelial outgrowth cells (EOCs) are still unclear. Clarifications of their respective properties and specific functioning characteristics contribute to better applications of EPCs in ischemic diseases. In this review, we discuss cellular origin, isolation, culture, surface markers of early EPCs and EOCs and relevant applications in neurological diseases. We conclude that EOCs possess all haracteristics of true endothelial progenitors and have potent advantages in EPC-based therapies for ischemic diseases. A number of preclinical and clinical applications of EPCs in neurological diseases are under study. More studies are needed to determine the specific characteristics of EPCs and the relevant mechanisms of EPCs for neurological diseases.

Keyword

Early endothelial progenitor cells; Endothelial outgrowth cells; Cell origin; Surface antigen expression; Neurological disease

MeSH Terms

Classification*
Endothelial Progenitor Cells
Stroke
Therapeutic Uses
Therapeutic Uses