Blood Res.  2017 Sep;52(3):212-217. 10.5045/br.2017.52.3.212.

Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia

Affiliations
  • 1Department of Pathology, Lady Hardinge Medical College, New Delhi, India. dr.gunjan2003@gmail.com
  • 2Department of Paediatrics, Lady Hardinge Medical College, New Delhi, India.

Abstract

BACKGROUND
Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most prevalent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of iron status, is a homeostatic regulator of iron metabolism. We investigated the role of hepcidin and other conventional iron parameters to assess iron status among children with ACD and IDA. We also identified children with ACD who developed iron deficiency (ID).
METHODS
The study was undertaken in anemic children with 30 cases each of ACD and IDA along with 30 age and sex-matched controls. The ACD cases were subdivided into pure ACD and ACD with coexistent ID. All cases were subjected to following tests: complete blood count with peripheral smear, serum C-reactive protein, serum interleukin-6, iron studies, serum soluble transferrin receptor (sTfR), and serum hepcidin.
RESULTS
The mean serum hepcidin concentration was significantly increased in pure ACD patients (143.85±42.76 ng/mL) as compared to those in IDA patients (6.01±2.83 ng/mL, P < 0.001) and controls (24.96±9.09 ng/mL, P <0.001). Also, compared to pure ACD patients [normal sTfR levels (<3 µg/mL)], the serum hepcidin concentration was reduced significantly in ACD patients with ID [high sTfR levels (≥3 µg/mL)] with a mean of 10.0±2.97 ng/mL.
CONCLUSION
Hepcidin measurement can provide a useful tool for differentiating ACD from IDA and also help to identify an iron deficiency in ACD patients. This might aid in the appropriate selection of therapy for these patients.

Keyword

Hepcidin; Anemia of chronic disease; Iron deficiency anemia; Children

MeSH Terms

Anemia*
Anemia, Iron-Deficiency*
Blood Cell Count
C-Reactive Protein
Child*
Chronic Disease*
Hepcidins*
Humans
Interleukin-6
Iron*
Metabolism
Receptors, Transferrin
C-Reactive Protein
Interleukin-6
Iron
Receptors, Transferrin

Figure

  • Fig. 1 Correlation between ferritin and hepcidin concentrations in the pure ACD and IDA groups.

  • Fig. 2 Correlation of IL-6 and serum hepcidin concentrations in patients with ACD.


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