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Predictive Value of Plasma NGAL:Hepcidin-25 for Major Adverse Kidney Events After Cardiac Surgery with Cardiopulmonary Bypass: A Pilot Study

Albert C, Haase M, Albert A, Ernst M, Kropf S, Bellomo R, Westphal S, Braun-Dullaeus RC, Haase-Fielitz A, Elitok S

Background: Neutrophil gelatinase-associated lipocalin (NGAL) and hepcidin-25 are involved in catalytic iron-related kidney injury after cardiac surgery with cardiopulmonary bypass. We explored the predictive value of plasma NGAL, plasma hepcidin-25,...
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Can Calprotectin Show Subclinical Inflammation in Familial Mediterranean Fever Patients?

Asan G, Derin ME, DoÄŸan HO, Bayram M, Åžahin M, Åžahin A

BACKGROUND: Familial Mediterranean fever (FMF) is an autoinflammatory disease that has self-limiting inflammatory attacks during polyserositis. Hepcidin is a protein, and interleukin-6 stimulation increases hepcidin levels. Calprotectin (CLP) is a...
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Urinary Biomarkers may Complement the Cleveland Score for Prediction of Adverse Kidney Events After Cardiac Surgery: A Pilot Study

Albert C, Haase M, Albert A, Kropf S, Bellomo R, Westphal S, Westerman , Braun-Dullaeus RC, Haase-Fielitz A

BACKGROUND: The ability of urinary biomarkers to complement established clinical risk prediction models for postoperative adverse kidney events is unclear. We assessed the effect of urinary biomarkers linked to suspected...
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Hepcidin and Neutrophil Gelatinase-Associated Lipocalin as a Biomarker for Acute Kidney Injury Linked Iron Metabolism

Cho SY, Hur M

No abstract available.
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Iron Deficiency Anemia

Lee NH

Iron deficiency anemia (IDA) is a common medical problem that affects an estimated 30-50% of the world’s population. The causes of IDA are malnutrition, rapid growth with improper dietary iron,...
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Relationship between Cardiac Geometry and Serum Hepcidin in Chronic Kidney Disease: Analysis from the KNOW-CKD Study

Min HK, Oh YK, Choi KH, Lee KB, Park SK, Ahn C, Lee SW

BACKGROUND: Few studies have examined the relationship between cardiac function and geometry and serum hepcidin levels in patients with chronic kidney disease (CKD). We aimed to identify the relationship between...
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Role of redox iron towards an increase in mortality among patients: a systemic review and meta-analysis

Sharma S

An increase in biochemical concentrations of non-transferrin bound iron (NTBI) within the patients with an increase in serum iron concentration was evaluated with the following objectives: (a) Iron overloading diseases/conditions...
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Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder

Yazici KU, Yazici IP, Ustundag B

OBJECTIVE: In this study, we aimed to evaluate the serum hepcidin levels in attention deficit hyperactivity disorder (ADHD) patients that were newly diagnosed with no history of psychotropic drugs. METHODS: A...
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New Oral Agent for Treatment of Anemia in Patient with Chronic Kidney Disease: Prolyl Hydroxylase Inhibitor

Na K

Hypoxia inducible factor (HIF)-stabilizers are being developed for the renal anemia treatment. This small molecules inhibit prolyl hydroxylase domain (PHD)-containing enzymes, causing HIF activation instead of degradation under the state...
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Basic Understanding of Iron Metabolism

Suh JK, Jeon IS

Iron is critical for almost all living organisms because it serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism. Disruption of iron homeostasis is...
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Treatment of renal anemia: Erythropoiesis stimulating agents and beyond

Biggar P, Kim GH

Anemia, complicating the course of chronic kidney disease, is a significant parameter, whether interpreted as subjective impairment or an objective prognostic marker. Renal anemia is predominantly due to relative erythropoietin...
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Hepcidin and iron parameters in children with anemia of chronic disease and iron deficiency anemia

Mahajan G, Sharma S, Chandra J, Nangia A

BACKGROUND: Anemia of chronic disease (ACD) and iron deficiency anemia (IDA) are the two most prevalent forms of anemia having interrelated characteristics. Hepcidin, a newly introduced biomarker for assessment of...
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Clinical and Hematological Effects of Tocilizumab on Serum Hepcidin, Anemia Response and Disease Activity in Patients with Active Rheumatoid Arthritis

Park KJ, Jin HM, Cho YN, Kang JH, Jung HJ, Kang JH, Kim JE, Yim YR, Lee JW, Lee KE, Park DJ, Kim TJ, Lee SS, Kee SJ, Park YW

OBJECTIVE: The purpose of this study is to evaluate the clinical and hematological effects of tocilizumab in active rheumatoid arthritis (RA) patients. METHODS: Fourteen patients with active RA were enrolled in...
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Hepcidin Level and Iron Parameters in Patients with Chronic Kidney Disease

Seo JY, Song YH, Park MJ, Kim MJ, Seo YH, Ahn JY, Kim KH, Jeong JH, Chung W, Park PW

BACKGROUND: Hepcidin, a key regulator of iron homeostasis, is associated with iron metabolism imbalance in patients with chronic kidney disease (CKD). However, serum hepcidin level in anemic patients with CKD...
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Serum Hepcidin Level as an Early Marker of Hematopoietic Activity after Allogeneic Peripheral Blood Stem Cell Transplantation

Kim J, Kwon KC, Koo SH

  • KMID: 2200509
  • J Lab Med Qual Assur.
  • 2013 Jun;35(1):1-7.
BACKGROUND: Hepcidin plays a central role in the regulation of iron metabolism, and hepatic iron production is stimulated by iron load and inflammation. Recent animal studies have shown that hepcidin...
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Role of hepcidin in the pathophysiology and diagnosis of anemia

D'Angelo G

This review summarizes the central role of hepcidin in the iron homeostasis mechanism, the molecular mechanism that can alter hepcidin expression, the relationship between hepcidin and erythropoiesis, and the pathogenetic...
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Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease

Larson DS, Coyne DW

  • KMID: 2224314
  • Kidney Res Clin Pract.
  • 2013 Mar;32(1):11-15.
Hepcidin, produced by the liver, is the master regulator of iron balance. Serum hepcidin is increased by high iron stores, blocks intestinal iron absorption, and impairs storage iron release. Conversely,...
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Serum hepcidin levels and iron parameters in children with iron deficiency

Choi HS, Song SH, Lee JH, Kim HJ, Yang HR

BACKGROUND: Iron deficiency (ID) and iron deficiency anemia (IDA) are common nutritional disorders in children. Hepcidin, a peptide hormone produced in the liver, is a central regulator of systemic iron...
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Serum Pro-hepcidin as an Predictor of Iron Deficiency in Anemic Patients

Kim J, Son Y, Ihm C

BACKGROUND: Hepcidin has recently been known as a negative regulatory hormone of iron. Hepcidin precursor, pro-hepcidin has been used as a surrogate and reported to be related to iron deficiency....
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Serum prohepcidin levels in chronic hepatitis C, alcoholic liver disease, and nonalcoholic fatty liver disease

Lee SH, Jeong SH, Park YS, Hwang JH, Kim JW, Kim N, Lee DH

BACKGROUND/AIMS: Patients with various chronic liver diseases frequently have increased body iron stores. Prohepcidin is an easily measurable precursor of hepcidin, which is a key regulator of iron homeostasis. This...
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