Blood Res.  2019 Mar;54(1):10-16. 10.5045/br.2019.54.1.10.

Molecular perspective of iron uptake, related diseases, and treatments

• Shokrgozar N
• Golafshan

• KMID: 2451050
• DOI: http://doi.org/10.5045/br.2019.54.1.10

Abstract

Iron deficiency anemia and anemia of chronic disorders are the most common types of anemia. Disorders of iron metabolism lead to different clinical scenarios such as iron deficiency anemia, iron overload, iron overload with cataract and neurocognitive disorders. Regulation of iron in the body is a complex process and different regulatory proteins are involved in iron absorption and release from macrophages into hematopoietic tissues. Mutation in these regulatory genes is the most important cause of iron refractory iron deficiency anemia (IRIDA). This review provides a glance into the iron regulation process, diseases related to iron metabolism, and appropriate treatments at the molecular level.

Keyword

Iron metabolism; Iron deficiency anemia; Iron regulation

MeSH Terms

Absorption
Anemia
Anemia, Iron-Deficiency
Cataract
Genes, Regulator
Iron Overload
Iron*
Macrophages
Metabolism
Neurocognitive Disorders
Iron