Korean J Nucl Med.  1998 Feb;32(1):114-119.

Altered Biodistribution of Gallium-67 in a Patient with Multiple Factors Influencing Iron-transport Protein Saturation

• Choi JY
• Kim SE
• Lee KH
• Kim BT

Abstract

We present a case of a young female patient with fulminant hepatitis who showed an altered biodistribution of Ga-67, after being scanned twice at 10 month intevals. On initial scan, uptake of Ga-67 was increased in the liver, kidneys, and skeletons. Increased hepatic Ga-67 uptake may be explained by increased transferrin unbound Ga-67 that was taken up by the inflamed liver. The saturation of iron-binding proteins due to multiple transfusions may lead to increased renal and skeletal Ga-67 uptake. On follow-up scan hepatic Ga-67 uptake was markedly increased. Also increased Ga-67 uptake in the axial skeleton and normalized renal uptake were shown. The findings were consistent with iron deficiency anemia. This case demonstrates altered Ga-67 biodistribution associated with multiple transfusions, fulminant hepatitis, and iron deficiency anemia.

Keyword

Gallium-67; Fulminant hepatitis; Iron deficiency anemia; Transfusion

MeSH Terms

Anemia, Iron-Deficiency
Female
Follow-Up Studies
Hepatitis
Humans
Iron-Binding Proteins
Kidney
Liver
Skeleton
Transferrin
Iron-Binding Proteins
Transferrin