Nucl Med Mol Imaging.  2017 Dec;51(4):347-349. 10.1007/s13139-017-0486-5.

Altered Biodistribution of (99m)Tc-DPD on Bone Scan After Intravenous Iron Supplement

• Shin E
• Oh M
• Sung C
• Kim KH
• Ryu JS

• KMID: 2403508
• DOI: http://doi.org/10.1007/s13139-017-0486-5

Abstract

We report a casewith altered biodistribution of (99m)Tc-dicarboxypropane diphosphonate ((99m)Tc-DPD) on whole body bone scan after intravenous iron supplement therapy. A 47-year-old male patient who had recently been detected with a hepatic mass suggestive of hepatocellular carcinoma underwent bone scan as staging work-up before surgery. Bone scan images at 3 h after injection of (99m)Tc-DPD demonstrated unusually increased blood pool activities in the heart, liver, and spleen with usual skeletal uptakes. The patient had been treated for severe anemia from hemorrhoid with two intravenous administration of ferric hydroxide carboxymaltose complex at approximately 22 h and 2 h prior to the (99m)Tc-DPD injection, which we consider as themost probable cause of altered biodistribution of (99m)Tc-DPD.

Keyword

Bone scan; (99m)Tc-DPD; Iron supplement; Biodistribution

MeSH Terms

Administration, Intravenous
Anemia
Carcinoma, Hepatocellular
Heart
Hemorrhoids
Humans
Iron*
Liver
Male
Middle Aged
Spleen
Iron