Ann Dermatol.  2017 Aug;29(4):400-406. 10.5021/ad.2017.29.4.400.

House Dust Mite Sensitization Is Inversely Associated with Plasma 25-Hydroxyvitamin D3 Levels in Patients with Severe Atopic Dermatitis

Affiliations
  • 1Department of Dermatology, Kyungpook National University School of Medicine, Daegu, Korea. shkim72@knu.ac.kr
  • 2Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Korea. kimdw@knu.ac.kr

Abstract

BACKGROUND
The relationship between atopic dermatitis (AD) and low vitamin D levels has been studied. Emerging evidence has implicated vitamin D as a critical regulator of immunity, playing a role in both the innate and cell-mediated immune systems. However, the effect of vitamin D on house dust mite (HDM) sensitization in patients with AD has not been established.
OBJECTIVE
We investigated the association between vitamin D levels and HDM sensitization according to AD severity.
METHODS
In total, 80 patients (43 men and 37 women) with AD were included. We classified AD severity using Rajka and Langeland scores. Laboratory tests included serum 25-hydroxyvitamin D3, total immunoglobulin E (IgE), and specific IgE antibody titer against Dermatophagoides farinae and D. pteronyssinus.
RESULTS
There were no differences in vitamin D levels between the mild or moderate AD and severe AD groups. In the severe AD group, high HDM sensitization group had lower serum vitamin D levels compared to low HDM sensitization group with statistical significance. In addition, a significant negative correlation was found between vitamin D levels and HDM sensitization in the severe AD group.
CONCLUSION
Our results demonstrate that low vitamin D levels may link to high HDM sensitization in patients with the severe AD. Further elucidation of the role of vitamin D in HDM sensitization may hold profound implications for the prevention and treatment of AD.

Keyword

Atopic dermatitis; Dermatophagoides farinae; Dermatophagoides pteronyssinus; Sensitization; Vitamin D

MeSH Terms

Calcifediol*
Dermatitis, Atopic*
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Dust*
Humans
Immune System
Immunoglobulin E
Immunoglobulins
Male
Plasma*
Pyroglyphidae*
Vitamin D
Calcifediol
Dust
Immunoglobulin E
Immunoglobulins
Vitamin D
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