Keimyung Med J.  2017 Jun;36(1):18-25. 10.0000/kmj.2017.36.1.18.

Assessment of Diabetic Peripheral Neuropathy Using Current Perception Threshold

• Kim KT
• Lee S

• KMID: 2388539
• DOI: http://doi.org/10.0000/kmj.2017.36.1.18

Abstract

The aim of this study was to compare the current perception threshold (CPT) with a nerve conduction study (NCS) to evaluate the usefulness of CPT in the diagnosis of diabetic Peripheral Neuropathy (DPN). CPT measurement is quantitative method for assessment of peripheral sensory nerve function using electrical impulse. Enrolled in this study were 142 patients with type 2 diabetes who underwent both CPT testing and NCS between January 2013 and April 2016. DPN was diagnosed by NCS. CPT was performed on the right index finger and great toe of each patient. Patients with burning, tingling sensation and with longer history of diabetes tended to have a higher prevalence of DPN. In all frequencies tested (2000, 250, 5 Hz), CPT values of the DPN group were higher than the normal group. After classification in either the normoesthesia or hypoesthesia group according to CPT, the DPN group had a significantly higher prevalence of hypoesthesia than normal group. The receiver operating characteristics curve analysis showed that CPT had a high area under curve value for predicting the presence of DPN. In conclusion, CPT measurement is clinically valuable in detecting nerve dysfunction in patients with type 2 diabetes.

Keyword

Current perception threshold; Diabetic neuropathy; Nerve conduction study

MeSH Terms

Area Under Curve
Burns
Classification
Diabetic Neuropathies
Diagnosis
Fingers
Humans
Hypesthesia
Methods
Neural Conduction
Peripheral Nervous System Diseases*
Prevalence
ROC Curve
Sensation
Toes