Korean J Dermatol.  2017 Jul;55(6):364-368.

Secondary Cutaneous Follicular B-Cell Lymphoma Associated with Erythematous Swelling on the Leg: A Case Report

• Kim DJ
• Lee SK
• Lee UH
• Kim MS

Abstract

Cutaneous follicular B-cell lymphoma (CFBCL) is defined as the neoplastic proliferation of germinal center cells confined to the skin. Secondary CFBCL demonstrates a more aggressive clinical course compared to the primary form. We report the case of a 45-year-old man who presented with a 15-day history of lesions on his right leg. Clinical examination revealed multiple erythematous miliary/agminated papules on the right proximal thigh with erythematous swollen patches on the right lower leg. Biopsy of a thigh lesion revealed a massive dermal lymphocytic infiltrate with a follicular pattern. Immunohistochemical staining revealed atypical lymphocytes, which strongly expressed CD20, CD10, Bcl-2, Bcl-6 and Ki-67 proteins, but not CD3 and Cyclin D1. Additionally, further studies revealed that this cutaneous lesion had originated from a retroperitoneal lymph node. We treated the patient with systemic chemotherapy using a cyclophosphamide, hydroxydaunorubicin, oncovin, and prednisone (CHOP) regimen and anti-CD20 monoclonal antibodies. This case illustrates a rarely reported example of secondary cutaneous follicular B-cell lymphoma showing peculiar clinical manifestations.

Keyword

Cutaneous follicular B-cell lymphoma; Miliary and agminated lesions; Secondary cutaneous B-cell lymphoma

MeSH Terms

Antibodies, Monoclonal
B-Lymphocytes*
Biopsy
Cyclin D1
Cyclophosphamide
Drug Therapy
Germinal Center
Humans
Leg*
Lymph Nodes
Lymphocytes
Lymphoma, B-Cell*
Middle Aged
Prednisone
Skin
Thigh
Vincristine
Antibodies, Monoclonal
Cyclin D1
Cyclophosphamide
Prednisone
Vincristine