J Korean Soc Laryngol Phoniatr Logoped.  2017 Jun;28(1):32-37. 10.0000/jkslpl.2017.28.1.32.

Treatment Result of Proton Pump Inhibitor, Steroid Inhaler and Botulinum Tonxin Injection for Contact Granuloma

• Park HM
• Oh NR
• Baek MK
• Kim DY
• Woo JH

• KMID: 2388201
• DOI: http://doi.org/10.0000/jkslpl.2017.28.1.32

Abstract

BACKGROUND AND OBJECTIVES
This study evaluated the efficacy of combination therapy of proton pump inhibitor (PPI) and steroid inhaler (SI), with or without botulinum toxin injection (BTX) for contact granuloma.
SUBJECTS AND METHODS
Fourteen contact granuloma patients were enrolled in this study. Combination therapy of PPI and SI were used for the first line treatment. When combination therapy was not effective, BTX was performed as the second method. Treatment results were recorded as responsible or non-responsible. Farwell grade, size, history of voice abuse, gender, and reflux finding score (RFS) were compared between responsible group and non-responsible group.
RESULTS
Initial response rate was 28.6% after treatment of PPI and SI. BTX was performed on three un-responsible patients. After BTX injection, three patients had complete remission of granuloma. Final response rate was 50.0%. Un-responsible group had significantly higher RFS than responsible group.
CONCLUSION
The efficacy of PPI and SI was limited for contact granuloma in this study. Botulium toxin injection was recommended in early phase when PPI and SI did not effective for contact granuloma. Prospective studies evaluating the effects of PPI and SI are warranted.

Keyword

Granuloma; Vocal cords; Proton pump inhibitor; Steroid

MeSH Terms

Botulinum Toxins
Granuloma*
Humans
Methods
Nebulizers and Vaporizers*
Prospective Studies
Proton Pumps*
Protons*
Vocal Cords
Voice
Botulinum Toxins
Proton Pumps
Protons