J Korean Soc Laryngol Phoniatr Logoped.  2017 Dec;28(2):123-127. 10.0000/jkslpl.2017.28.2.123.

Effectiveness of Proton Pump Inhibitor in the Treatment of Contact Granuloma

• Kim DH
• Kim KH
• Jung SM
• Song CM
• Ji YB
• Tae K

• KMID: 2402961
• DOI: http://doi.org/10.0000/jkslpl.2017.28.2.123

Abstract

BACKGROUND AND OBJECTIVES
Contact granuloma is granulation tissue that occurs mainly in the vocal process of arytenoid cartilage. Among several etiological factors, gastric acid reflux is known to be an important cause. The aim of this study was to evaluate clinical characteristics of contact granuloma and analyze the effectiveness of proton pump inhibitor in the treatment of contact granuloma.
MATERIALS AND METHODS
We retrospectively reviewed the medical records of 40 patients who were treated with proton pump inhibitor (PPI) for contact granuloma from January 2011 to December 2015. Reflux finding score (RFS), reflux symptom index (RSI) and size of granuloma were evaluated before and after treatment serially to assess the effectiveness of proton pump inhibitor.
RESULTS
Of 40 patients, 25 patients (62.5%) and 10 patients (25%) showed improvement and partial improvement of granuloma, respectively. Five patients showed no response. The mean times of partial improvement and improvement were 2.08±2.23 months and 4.60±2.77 months, respectively and mean duration of PPI treatment was 6.8±5.2 months.
CONCLUSION
Proton pump inhibitors is effective in the treatment of contact granuloma.

Keyword

Contact granuloma; Proton pump inhibitor; Laryngopharyngeal reflux; Gastroesophageal reflux

MeSH Terms

Arytenoid Cartilage
Gastroesophageal Reflux
Granulation Tissue
Granuloma*
Humans
Laryngopharyngeal Reflux
Medical Records
Proton Pump Inhibitors
Proton Pumps*
Protons*
Retrospective Studies
Proton Pump Inhibitors
Proton Pumps
Protons