J Korean Soc Laryngol Phoniatr Logoped.
2018 Dec;29(2):79-82. 10.0000/jkslpl.2018.29.2.79.
The Effect of Nasal Steroid Spray on Contact Granuloma of Larynx
- Affiliations
-
- 1Department of Otorhinolaryngology-Head and Neck Surgery, Kyungpook National University School of Medicine, Daegu, Korea. sohnjh@knu.ac.kr
- KMID: 2437325
- DOI: http://doi.org/10.0000/jkslpl.2018.29.2.79
Abstract
- BACKGROUND AND OBJECTIVES
Laryngeal contact granuloma is benign inflammatory disease induced by excessive mechanical contact of larynx such as endotracheal intubation, voice abuse, laryngeal microsurgery as well as laryngopharygeal reflux. Because it is caused by various risk factors, multiple treatment modalities are required. The purpose of study is to evaluate treatment effect of topical steroid through nasal cavity in contact granuloma. MATERIALS AND METHOD: Fifty-two patients were enrolled in this study with exception of intubation granuloma. Patients were classified with four groups (Proton pump inhibitor (PPI), Nasal steroid spray (SPR), PPI+SPR, Observation) according to treatment modality.
RESULTS
Patients who treated with PPI (Odds ratio 2.45, p=0.03) and combination of PPI and SPR (Odds ratio 2.88, p<0.01) had significantly better response than patients who not treated with medical therapy.
CONCLUSION
Combination therapy of nasal steroid spray and PPI is effective for contact granuloma of larynx and considered as a treatment of choice rather than PPI only treatment.
