J Korean Soc Laryngol Phoniatr Logoped.  2021 Dec;32(3):135-141. 10.22469/jkslp.2021.32.3.135.

Treatment Results of Vocal Process Granuloma: Intubation Versus Contact Granuloma

• Jeong JU
• Oh JH
• Kim S
• Kim DY
• Woo JH

• KMID: 2523514
• DOI: http://doi.org/10.22469/jkslp.2021.32.3.135

Abstract

Background and Objectives
Vocal process granulomas (VPGs) are benign lesions of the larynx, typically contact granulomas (CG) and intubation granulomas (IG). The two diseases are known to have different clinical manifestations despite having the same pathological features. The purpose of this study was to analyze the treatment results for CG and IG and to obtain clinical information. Materials and Method We retrospectively reviewed the medical records of patients diagnosed with VPG between January 2015 and December 2018. The patient’s age, sex, medical history, lesion size, lesion type, reflux finding score, response to treatment, duration of treatment, and follow-up period were compared.
Results
In total, 32 patients were included in the study, of which 18 were CG and 14 were IG. In the CG group, males were dominant (n=15, 83.3%), whereas in the IG group, females were dominant (n=11, 78.6%) (p=0.0009). The response to medical treatment using proton pump inhibitor and steroid inhaler was better in the IG group (11/14, 78.6%) than in the CG group (7/18, 38.9%) (p=0.036). Of the 14 patients who did not respond to medical treatment, 5 received botulium toxin injections, and all 5 had complete remission. The duration of medical treatment was significantly longer in the IG group (p=0.0029).
Conclusion
IG was more common in female, and CG was more dominant in male. IG had better response to medical treatment using proton pump inhibitor and steroid inhaler than CG.

Keyword

Vocal cords; Larynx; Granuloma; Proton pump inhibitors; Botulinum toxins.; 성대; 후두; 육아종; 양성자펌프억제제; 보툴리눔 독소.