Perinatology.  2017 Jun;28(2):35-40. 10.14734/PN.2017.28.2.35.

Association between Birth Weight and Bronchopulmonary Dysplasia in <32 Weeks of Singleton Infants

Affiliations
  • 1Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. joneona@cha.ac.kr

Abstract


OBJECTIVE
Intrauterine growth retardation of lung has been suggested as being one of the risk factors in the development of bronchopulmonary dysplasia (BPD). The aim of this study was to clarify birth weight percentile among Korean infants using the contemporary Korean reference curve for birth weight by gestational age published in 2014, and on the basis of that clarification, identify the association between birth weight percentile and BPD development.
METHODS
All newborn infants born at <32 weeks of gestation admitted to the neonatal intensive care unit of CHA Bundang Medical Center from January 2010 through December 2015 were reviewed. Infants were divided into BPD group and non-BPD group. BPD was defined as a need of oxygen or positive airway pressure at 36 weeks postmenstrual age. All prenatal and neonatal data were collected via retrospective chart review and analyzed by multivariate logistic regression analysis.
RESULTS
During the study period, 198 singleton infants were born at <32 weeks' gestation. Among these, 179 infants were included, 54 infants in BPD group and 125 infants in non-BPD group. According to logistic regression analysis, lower gestational age, lower birth weight percentile, occurrence of late onset sepsis showed increased risk of BPD (odds ratio [OR] 0.77, P=0.027; OR 0.98, P=0.021; OR 7.98, P<0.0001).
CONCLUSION
In this single center study, lower birth weight percentile in preterm infants seems to increase the risk of BPD. In these infants, anticipate the high risk of BPD and cautious treatment strategies are needed.

Keyword

Intrauterine growth retardation; Bronchopulmonary dysplasia; Preterm birth

MeSH Terms

Birth Weight*
Bronchopulmonary Dysplasia*
Fetal Growth Retardation
Gestational Age
Humans
Infant*
Infant, Newborn
Infant, Premature
Intensive Care, Neonatal
Logistic Models
Lung
Oxygen
Parturition*
Pregnancy
Premature Birth
Retrospective Studies
Risk Factors
Sepsis
Oxygen

Reference

1). Jo HS., Cho KH., Cho SI., Song ES., Kim BI. Recent changes in the incidence of bronchopulmonary dysplasia among very-low-birth-weight infants in Korea. J Korean Med Sci. 2015. 30(Suppl 1):S81–7.
Article
2). Latini G., De Felice C., Giannuzzi R., Del Vecchio A. Survival rate and prevalence of bronchopulmonary dysplasia in extremely low birth weight infants. Early Hum Dev. 2013. 89(Suppl 1):S69–73.
Article
3). Bancalari E., Claure N., Sosenko IR. Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definition. Semin Neonatol. 2003. 8:63–71.
Article
4). Van Marter LJ. Epidemiology of bronchopulmonary dysplasia. Semin Fetal Neonatal Med. 2009. 14:358–66.
Article
5). Briana DD., Malamitsi-Puchner A. Small for gestational age birth weight: impact on lung structure and function. Paediatr Respir Rev. 2013. 14:256–62.
Article
6). Merkus PJ., ten Have-Opbroek AA., Quanjer PH. Human lung growth: a review. Pediatr Pulmonol. 1996. 21:383–97.
Article
7). Reiss I., Landmann E., Heckmann M., Misselwitz B., Gortner L. Increased risk of bronchopulmonary dysplasia and increased mortality in very preterm infants being small for gestational age. Arch Gynecol Obstet. 2003. 269:40–4.
Article
8). Bose C., Van Marter LJ., Laughon M., O'Shea TM., Allred EN., Karna P, et al. Fetal growth restriction and chronic lung disease among infants born before the 28th week of gestation. Pediatrics. 2009. 124:e450–8.
Article
9). Le Guennec JC., Rufai M., Papageorgiou A. Spectrum of oxygen dependency in surviving infants weighing 600 to 1000 grams: decreased incidence of severe chronic lung disease. Am J Perinatol. 1993. 10:292–6.
Article
10). Lim JS., Lim SW., Ahn JH., Song BS., Shim KS., Hwang IT. New Korean reference for birth weight by gestational age and sex: data from the Korean Statistical Information Service (2008-2012). Ann Pediatr Endo-crinol Metab. 2014. 19:146–53.
Article
11). Jobe AH., Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001. 163:1723–9.
Article
12). Ehrenkranz RA., Walsh MC., Vohr BR., Jobe AH., Wright LL., Fanaroff AA, et al. Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 2005. 116:1353–60.
Article
13). Tita AT., Andrews WW. Diagnosis and management of clinical chorioamnionitis. Clin Perinatol. 2010. 37:339–54.
Article
14). Papile LA., Burstein J., Burstein R., Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978. 92:529–34.
Article
15). Bell MJ. Perforation of the gastrointestinal tract and peritonitis in the neonate. Surg Gynecol Obstet. 1985. 160:20–6.
16). International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited. Arch Ophthalmol. 2005. 123:991–9.
17). de Vries LS., Eken P., Dubowitz LM. The spectrum of leukomalacia using cranial ultrasound. Behav Brain Res. 1992. 49:1–6.
Article
18). Coalson JJ. Pathology of new bronchopulmonary dysplasia. Semin Neonatol. 2003. 8:73–81.
Article
19). Jobe AH. Let's feed the preterm lung. J Pediatr (Rio J). 2006. 82:165–6.
Article
20). Lal MK., Manktelow BN., Draper ES., Field DJ. Population-based study. Chronic lung disease of prematurity and intrauterine growth retardation: a population-based study. Pediatrics. 2003. 111:483–7.
Article
21). Zeitlin J., El Ayoubi M., Jarreau PH., Draper ES., Blondel B., Künzel W, et al. Impact of fetal growth restriction on mortality and morbidity in a very preterm birth cohort. J Pediatr. 2010. 157:733–9. .e1.
Article
22). Egreteau L., Pauchard JY., Semama DS., Matis J., Liska A., Romeo B, et al. Chronic oxygen dependency in infants born at less than 32 weeks' gestation: incidence and risk factors. Pediatrics. 2001. 108:E26.
Article
23). Lubchenco LO., Hansman C., Dressler M., Boyd E. Intrauterine growth as estimated from liveborn birth-weight data at 24 to 42 weeks of gestation. Pediatrics. 1963. 32:793–800.
Article
24). Lenoir S., Grandjean H., Leloup M., Claris O., Hascoet JM. Short and midterm outcome of a cohort of 1157 newborn infants with respiratory distress syndrome. Arch Pediatr. 1994. 1:1004–10.
25). Shahzad T., Radajewski S., Chao CM., Bellusci S., Ehrhardt H. Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development. Mol Cell Pediatr. 2016. 3:23.
Article
26). Mittendorf R., Covert R., Montag AG., elMasri W., Muraskas J., Lee KS, et al. Special relationships between fetal inflammatory response syndrome and bronchopulmonary dysplasia in neonates. J Perinat Med. 2005. 33:428–34.
Article
27). Yoon BH., Romero R., Jun JK., Park KH., Park JD., Ghezzi F, et al. Amniotic fluid cytokines (interleukin-6, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-8) and the risk for the development of bronchopulmonary dysplasia. Am J Obstet Gynecol. 1997. 177:825–30.
28). Ballard AR., Mallett LH., Pruszynski JE., Cantey JB. Chorioamnionitis and subsequent bronchopulmonary dysplasia in very-low-birth weight infants: a 25-year cohort. J Perinatol. 2016. 36:1045–8.
Article
29). Lahra MM., Beeby PJ., Jeffery HE. Intrauterine inflammation, neonatal sepsis, and chronic lung disease: a 13-year hospital cohort study. Pediatrics. 2009. 123:1314–9.
Article
30). Plakkal N., Soraisham AS., Trevenen C., Freiheit EA., Sauve R. Histological chorioamnionitis and bronchopulmonary dysplasia: a retrospective cohort study. J Perinatol. 2013. 33:441–5.
Article
31). Hartling L., Liang Y., Lacaze-Masmonteil T. Chorioamnionitis as a risk factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch Dis Child Fetal Neonatal Ed. 2012. 97:F8–17.
Article
32). Van Marter LJ., Dammann O., Allred EN., Leviton A., Pagano M., Moore M, et al. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr. 2002. 140:171–6.
Article
33). Elimian A., Verma U., Beneck D., Cipriano R., Visintainer P., Tejani N. Histologic chorioamnionitis, antenatal steroids, and perinatal outcomes. Obstet Gynecol. 2000. 96:333–6.
Article
34). Rojas MA., Gonzalez A., Bancalari E., Claure N., Poole C., Silva-Neto G. Changing trends in the epidemiology and pathogenesis of neonatal chronic lung disease. J Pediatr. 1995. 126:605–10.
Article
35). Spafford PS., Sinkin RA., Cox C., Reubens L., Powell KR. Prevention of central venous catheter-related coagulase-negative staphylococcal sepsis in neonates. J Pediatr. 1994. 125:259–63.
Article
36). Liljedahl M., Bodin L., Schollin J. Coagulase-negative staphylococcal sepsis as a predictor of bronchopulmonary dysplasia. Acta Paediatr. 2004. 93:211–5.
Article
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