Neonatal Med.  2014 May;21(2):114-121. 10.5385/nm.2014.21.2.114.

Optimal Ventilatory Strategies in Preterm Infants: Permissive Hypercapnia

• Hwang JH

• KMID: 2052157
• DOI: http://doi.org/10.5385/nm.2014.21.2.114

Abstract

Bronchopulmonary dysplasia associated with lung injury is an important morbidity in extremely low birth weight infants. Lung injury during mechanical ventilation is associated with high tidal volume and high end-inspiratory lung volume. Lung injury and bronchopulmonary dysplasia may be prevented with ventilatory strategies using optimal gas exchange such as permissive hypercapnia. This article will review the pathophysiologic background of lung injury and the current therapeutic ventilatory strategies such as permissive hypercapnia to reduce lung injury in preterm infants.

Keyword

Pulmonary ventilation; Bronchopulmonary dysplasia; Hypercapnia; Infant; Newborn

MeSH Terms

Bronchopulmonary Dysplasia
Humans
Hypercapnia*
Infant
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Lung
Lung Injury
Pulmonary Ventilation
Respiration, Artificial
Tidal Volume