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Medical Utilization and Costs in Preterm Infants in the First 6 Years of Life After Discharge From Neonatal Intensive Care Unit: A Nationwide Population-Based Study in Korea

Jin JH, Lee SA, Yoon SW

Background: The improvement in the survival rate of preterm infants has paradoxically raised the risk of morbidities in childhood. Our objectives were to assess the medical utilization and costs in...
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Vaginal health in women and the possibility of predicting preterm birth through microbiome analysis

Hur YM, Kang MN, Kim YJ

Background: With the recent development of next-generation sequencing technology, the microbiome in the body is being revealed in detail. It is also possible to describe the normal vaginal microenvironment and,...
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Prophylactic Cerclage to Prevent Preterm Birth after Conization: A Cohort Study Using Data from the National Health Insurance Service of Korea

Park HS, Kim HS, Lee SA, Yoon J, Kim EH

Purpose: To investigate potential differences in the frequency of preterm births (PTB) between pregnancies with or without prophylactic cerclage in women with a history of conization. Materials and Methods: We identified...
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Adverse Birth Outcomes Among Pregnant Women With and Without COVID-19: A Comparative Study From Bangladesh

Binte Masud S, Zebeen F, Alam DW, Hossian M, Zaman S, Begum RA, Nabi MH, Hawlader MDH

Objectives: Pregnant women are especially vulnerable to respiratory infections such as coronavirus disease 2019 (COVID-19), but insufficient research has investigated pregnancy and its outcomes in women with COVID-19. This cross-sectional...
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17-alpha hydroxyprogesterone caproate for the prevention of recurrent preterm birth among singleton pregnant women with a prior history of preterm birth: a systematic review and meta-analysis of six randomized controlled trials

Baradwan S, Abdulghani SH, Abuzaid M, Khadawardi K, Alshahrani MS, Al-Matary A, AlRasheed MA, Miski NT, Abdulhalim A, Alturki YM, Abu-Zaid A

To perform a systematic review and meta-analysis of all randomized controlled trials (RCTs) that investigated the clinical benefits of 17-alpha hydroxyprogesterone caproate (17OHPC) in the prevention of recurrent preterm birth...
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Funisitis as a Risk Factor for Adverse Neonatal Outcomes in Twin Neonates with Spontaneous Preterm Birth: A Retrospective Cohort Study

Hong S, Jeong M, Oh S, Oh JW, Park CW, Park JS, Jun JK, Lee SM

Purpose: Funisitis, inflammation of the umbilical cord, is considered a strong risk factor for adverse neonatal outcomes; however, a clinical definition of funisitis has not been established. In this study,...
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Iatrogenic Prelabor Premature Rupture of Membrane and Preterm Birth: an Experimental Mouse Study

Wang EJ, Kim HY, Cho GJ, Hong SC, Oh MJ, Kim HJ, Ahn KH

Objective We aimed to investigate whether mouse mothers born prematurely give birth to preterm pups. Methods Sexually mature female C57BL/6 mice were used. To create the pPROM model, the fetal membranes of the...
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Serum Ferritin Concentration in the Early Third Trimester of Pregnancy and Risk of Preterm Birth and Low Birth Weight Based on Gestational Age

Ahn TG, Li L, Lee SJ, Hu YH, Kim C, Hwang JY

Objective: Although serum ferritin is considered the best measure of total body iron, with low levels indicating iron deficiency, recent studies have shown that high levels are associated with gestational...
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The effects of maternal body mass index and plurality on maternal and umbilical cord serum magnesium levels in preterm birth at less than 32 weeks of gestation

Choi YS, Hong JY, Hong JY, Kim YM, Sung JH, Choi SJ, Oh Sy, Roh CR, Kim HS, Sung SI, Ahn SY, Chang YS

Objective To evaluate the effects of maternal body mass index (BMI) and plurality on maternal and umbilical cord serum magnesium levels after antenatal magnesium sulfate treatment. Methods This was a retrospective...
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A Review on the Effects of Melatonin on Fetal Protection during Pregnancy with Intrauterine Inflammation

Kim JM, Lee JY

Intrauterine inflammation is defined as the inflammation of the chorion, amnion, and placenta. Untreated inflammation increases the risk of fetal inflammatory response syndrome, which may result in multiorgan diseases involving...
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Role of Parental Social Class in Preterm Births and Low Birth Weight in Association with Child Mortality:A National Retrospective Cohort Study in Korea

Son M, An SJ, Choe SA, Park M, Kim YJ

Purpose: We explored the role of parental social class in preterm birth (PTB) and low birth weight (LBW) in association with child mortality in Korea. Materials and Methods: A total of...
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Cervicovaginal fluid cytokines as predictive markers of preterm birth in symptomatic women

Park S, You YA, Yun H, Choi SJ, Hwang HS, Choi SK, Lee SM, Kim YJ

Objective Here, we investigated whether cytokines in the cervicovaginal fluid (CVF) can be predictive markers of preterm birth (PTB). Methods A multi-center prospective cohort study was conducted on 59 singleton pregnant...
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Cervical pessary for preterm twin pregnancy in women with a short cervix

Jung DU, Choi MJ, Jung SY, Kim SY

Objective We aimed to evaluate the effectiveness of cervical pessary for extending twin pregnancy in women with a short cervix. Methods Between January 2014 and March 2019, the use of a cervical pessary for...
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Cognitive Ability and Related Factors in Preschoolers Born Prematurely

Ahn YM, Lee S

PURPOSE: This study was conducted to evaluate cognitive ability in preschoolers born prematurely and to investigate related factors. METHODS: A prospective, longitudinal study was conducted with 64 children at 5–6 years...
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How much have the perinatal outcomes of triplet pregnancies improved over the last two decades?

Kyeong KS, Shim JY, Oh SY, Won HS, Lee PR, Kim A, Yun SC, Kang PN, Choi SJ, Roh CR

OBJECTIVE: This study was conducted to demonstrate the temporal trends in perinatal outcomes of triplet pregnancies over the last two decades. METHODS: The medical records of patients with triplet pregnancies at...
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Initiation of human parturition: signaling from senescent fetal tissues via extracellular vesicle mediated paracrine mechanism

Menon R

A better understanding of the underlying mechanisms by which signals from the fetus initiate human parturition is required. Our recent findings support the core hypothesis that oxidative stress (OS) and...
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Artificial Neural Network Analysis of Spontaneous Preterm Labor and Birth and Its Major Determinants

Lee KS, Ahn KH

BACKGROUND: Little research based on the artificial neural network (ANN) is done on preterm birth (spontaneous preterm labor and birth) and its major determinants. This study uses an ANN for...
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Differential expression and methylation of integrin subunit alpha 11 and thrombospondin in the amnion of preterm birth

Yoo JY, You YA, Kwon EJ, Park MH, Shim S, Kim YJ

OBJECTIVE: This study aimed to investigate the association between preterm birth and epigenetic mechanisms in the amnion. METHODS: We examined the association between differentially methylated regions (DMRs) and differentially expressed genes...
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Recurrent Risk of Preterm Birth in the Third Pregnancy in Korea

Ouh YT, Park JH, Ahn KH, Hong SC, Oh MJ, Kim HJ, Han SW, Cho GJ

BACKGROUND: Although preterm delivery is the most common cause of infant morbidity and mortality, an obvious cause cannot be found in most cases. Preterm delivery is known to be the...
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Adiposity Measurements and Related Characteristics of Young Children Born Prematurely

Ahn Y, Sohn M, Lee S

PURPOSE: This study was conducted to measure adiposity and to investigate related factors in preschoolers born prematurely. METHODS: A longitudinal follow-up study was conducted with 52 preschoolers at 5 years of...
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