Nucl Med Mol Imaging.  2016 Dec;50(4):344-347. 10.1007/s13139-016-0408-y.

Unusual Uptake of Prostate Specific Tracer ⁶⁸Ga-PSMA-HBED-CC in a Benign Thyroid Nodule

• Damle NA
• Tripathi M
• Chakraborty PS
• Sahoo MK
• Bal C
• Aggarwal S
• Arora G
• Kumar P
• Kumar R
• Gupta R

• KMID: 2386158
• DOI: http://doi.org/10.1007/s13139-016-0408-y

Abstract

⁶⁸Ga-Prostate specific membrane antigen- N,N'- bis[2-hydroxy-5-(carboxyethyl)benzyl]ethylenediamine-N,N '-diacetic acid- positron emission tomography/computed tomography or 68 Ga- HBED-CC-PSMA PET/CT, popularly known as PSMA PET/CT, is able to detect a small volume of recurrent prostate carcinoma (PC) when there is a prostate specific antigen (PSA) rise on follow-up after prostatectomy or other definitive treatment for PC. The use of PSMA PET/ CTin the initial staging in PC is uncertain at this time. Clinical studies are underway to define its exact role in the management of the disease. At the same time it is important to be aware of unexpected sites of uptake of this ligand.We present here the case of a 62-year-old male patient who underwent prostatectomy for adenocarcinoma prostate. He also had a long-standing left solitary thyroid nodule (STN). Four months after surgery, he had a rising trend in serum PSA levels on three occasions, but the absolute value was less than 4 at all times. He underwent a ⁶⁸Ga-PSMA-HBED-CC PET/CT, but it did not reveal any recurrent/metastatic site of disease. However, there was increased tracer uptake in the left STN. Fine needle aspiration cytology revealed features of atypia of undetermined significance, Bethesda category III. The patient underwent a left hemithyroidectomy and the histopathology showed features of a follicular adenoma.

Keyword

⁶⁸Gallium; PET/CT; Prostate carcinoma; PSMA

MeSH Terms

Adenocarcinoma
Adenoma
Biopsy, Fine-Needle
Electrons
Follow-Up Studies
Humans
Male
Membranes
Middle Aged
Positron-Emission Tomography and Computed Tomography
Prostate*
Prostate-Specific Antigen
Prostatectomy
Thyroid Gland*
Thyroid Nodule*
Prostate-Specific Antigen