J Rheum Dis.  2017 Jun;24(3):165-168. 10.4078/jrd.2017.24.3.165.

Hypereosinophilic Syndrome Associated with the Onset of Rheumatoid Arthritis: A Case Report

Affiliations
  • 1Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Korea.
  • 2Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine of Chonbuk National University Hospital, Jeonju, Korea. ywhim@jbnu.ac.kr
  • 3Division of Pulmonology and Allergy, Department of Internal Medicine, Chonbuk National University Hospital, Jeonju, Korea.

Abstract

Idiopathic hypereosinophilic syndrome (HES) is a disorder characterized by the sustained overproduction of eosinophils and multiple organ damage. Rheumatologic manifestations of HES are infrequent, but persistent eosinophilia is observed in approximately 10% to 40% of patients with rheumatoid arthritis (RA). This finding may be a result of the RA itself and is often associated with active disease and the presence of extra-articular features. We describe the case of a 48-year-old man affected by HES who subsequently developed RA. Both HES and RA responded rapidly to the corticosteroid and methotrexate therapy. In this patient, the initiation of RA and HES was related, suggesting a common pathogenetic link between these two diseases.

Keyword

Hypereosinophilic syndrome; Rheumatoid arthritis

MeSH Terms

Arthritis, Rheumatoid*
Eosinophilia
Eosinophils
Humans
Hypereosinophilic Syndrome*
Methotrexate
Middle Aged
Methotrexate
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