J Korean Rheum Assoc.  2003 Jun;10(2):200-205.

A Case of Seronegative Rheumatoid Arthritis with Idiopathic Hypereosinophilic Syndrome

• Choi JH
• Jung JW
• Song HJ
• Song KE
• Choi JH
• Suh YJ
• Park HS
• Suh CH

Abstract

The idiopathic hypereosinophilic syndrome (HES) is a disorder marked by the sustained overproduction of eosinophils. The disease is characterized by damage of multiple organ including heart, nerve system, skin and lung due to eosinophilic infiltration and the diagnosis is one of exclusion. Rheumatologic manifestations of HES are infrequent. In about 10~40% of rheumatoid arthritis (RA) patients, persistent eosinophilia is observed. That can be due to the RA itself and is often associated with active disease and extra-articular features. Sometimes, it is attributed to the drug therapy, especially gold and penicillamine. We would like to report a 37-year-old female patient with HES who developed seronegative RA 2 years later.

Keyword

Idiopathic hypereosinophilic syndrome; Seronegative rheumatoid arthritis

MeSH Terms

Adult
Arthritis, Rheumatoid*
Diagnosis
Drug Therapy
Eosinophilia
Eosinophils
Female
Heart
Humans
Hypereosinophilic Syndrome*
Lung
Penicillamine
Skin
Penicillamine