J Clin Neurol.  2016 Oct;12(4):452-459. 10.3988/jcn.2016.12.4.452.

Asymmetric and Upper Body Parkinsonism in Patients with Idiopathic Normal-Pressure Hydrocephalus

Affiliations
  • 1Department of Neurology, Kyungpook National University School of Medicine, Daegu, Korea. neuromd@knu.ac.kr
  • 2Brain Science & Engineering Institute, Kyungpook National University, Daegu, Korea.
  • 3Kyungpook National University School of Medicine, Daegu, Korea.
  • 4Department of Neurosurgery, Kyungpook National University School of Medicine, Daegu, Korea.

Abstract

BACKGROUND
AND PURPOSE: Our aims were to analyze the characteristics of parkinsonian features and to characterize changes in parkinsonian motor symptoms before and after the cerebrospinal fluid tap test (CSFTT) in idiopathic normal-pressure hydrocephalus (INPH) patients.
METHODS
INPH subjects were selected in consecutive order from a prospectively enrolled INPH registry. Fifty-five INPH patients (37 males) having a positive response to the CSFTT constituted the final sample for analysis. The mean age was 73.7±4.7 years. The pre-tap mean Unified Parkinson's Disease Rating Scale motor (UPDRS-III) score was 24.5±10.2.
RESULTS
There was no significant difference between the upper and lower body UPDRS-III scores (p=0.174). The parkinsonian signs were asymmetrical in 32 of 55 patients (58.2%). At baseline, the Timed Up and Go Test and 10-meter walking test scores were positively correlated with the total motor score, global bradykinesia score, global rigidity score, upper body score, lower body score, and postural instability/gait difficulties score of UPDRS-III. After the CSFTT, the total motor score, global bradykinesia score, upper body score, and lower body score of UPDRS-III significantly improved (p<0.01). There was a significant decrease in the number of patients with asymmetric parkinsonism (p<0.05).
CONCLUSIONS
In the differential diagnosis of elderly patients presenting with asymmetric and upper body parkinsonism, we need to consider a diagnosis of INPH. The association between gait function and parkinsonism severity suggests the involvement of similar circuits producing gait and parkinsonian symptoms in INPH.

Keyword

normal pressure hydrocephalus; parkinsonism; Parkinson's disease
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