Endocrinol Metab.  2014 Dec;29(4):443-449. 10.3803/EnM.2014.29.4.443.

Lipid Accumulation Product Is Associated with Insulin Resistance, Lipid Peroxidation, and Systemic Inflammation in Type 2 Diabetic Patients

• Mirmiran P
• Bahadoran
• Azizi F

• KMID: 2384240
• DOI: http://doi.org/10.3803/EnM.2014.29.4.443

Abstract

BACKGROUND
Lipid accumulation product (LAP) is a novel biomarker of central lipid accumulation related to risk of diabetes and cardiovascular disease. In this study, we assessed the association of LAP with glucose homeostasis, lipid and lipid peroxidation, and subclinical systemic inflammation in diabetic patients.
METHODS
Thirty-nine male and 47 female type 2 diabetic patients were assessed for anthropometrics and biochemical measurements. LAP was calculated as [waist circumference (cm)-65]x[triglycerides (mmol/L)] in men, and [waist circumference (cm)-58]x[triglycerides (mmol/L)] in women. Associations of LAP with fasting glucose, insulin, insulin resistance index, lipid and lipoprotein levels, malondialdehyde, and high-sensitive C-reactive protein (hs-CRP) were assessed.
RESULTS
Mean age and LAP index were 53.6+/-9.6 and 51.9+/-31.2 years, respectively. After adjustments for age, sex and body mass index status, a significant positive correlation was observed between LAP index and fasting glucose (r=0.39, P<0.001), and homeostasis model assessment of insulin resistance (r=0.31, P<0.05). After additional adjustment for fasting glucose levels, antidiabetic and antilipidemic drugs, the LAP index was also correlated to total cholesterol (r=0.45, P<0.001), high density lipoprotein cholesterol (HDL-C) levels (r=-0.29, P<0.05), triglycerides to HDL-C ratio (r=0.89, P<0.001), malondialdehyde (r=0.65, P<0.001), and hs-CRP levels (r=0.27, P<0.05).
CONCLUSION
Higher central lipid accumulation in diabetic patients was related to higher insulin resistance, oxidative stress and systemic inflammation.

Keyword

Diabetes mellitus, type 2; Lipid accumulation product; Subclinical inflammation; Oxidative stress

MeSH Terms

Body Mass Index
C-Reactive Protein
Cardiovascular Diseases
Cholesterol
Cholesterol, HDL
Diabetes Mellitus, Type 2
Fasting
Female
Glucose
Homeostasis
Humans
Inflammation*
Insulin
Insulin Resistance*
Lipid Accumulation Product*
Lipid Peroxidation*
Lipoproteins
Male
Malondialdehyde
Oxidative Stress
Triglycerides
C-Reactive Protein
Cholesterol
Cholesterol, HDL
Glucose
Insulin
Lipoproteins
Malondialdehyde
Triglycerides

Figure

• 

  Fig. 1 Linear association of lipid accumulation product (LAP) and metabolic parameters in type 2 diabetic patients (regression curve estimation models were used). (A) Linear association of LAP and malondialdehyde (β=0.58, P<0.01). (B) Linear association of LAP with C-reactive protein (β=0.27, P<0.05). (C) Linear association of LAP with the triglycerides to high density lipoprotein cholesterol (HDL-C) ratio (β=0.91, P<0.01). (D) Linear association of LAP with fasting serum glucose (β=0.39, P<0.05). (E) Linear association of LAP with homeostasis model assessment of insulin resistance (β=0.31, P<0.05). (F) Linear association of LAP with serum total cholesterol (β=0.42, P<0.01).

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