J Korean Soc Pediatr Endocrinol.  2011 Aug;16(2):106-111.

Effect of GnRH Analogs Leuprolide-Acetate and Triptorelin on Bone Mineral Density in Girls with Central Precocious Puberty

• Bauer S
• Nam HK
• Rhie YJ
• Park SH
• Lee KH

Abstract

PURPOSE
The objective of this study was to evaluate the effect of gonadotropin releasing hormone analog (GnRHa) treatment on bone mineral density (BMD) in girls with central precocious puberty (CPP). Further we investigated the differences in the effect on BMD by using the GnRHa leuprolide-acetate and triptorelin.
METHODS
Sixty-one females with CPP were enrolled in the study, the lumbar spine BMD was measured by dual energy x-ray absorptiometry before treatment, after one year (n = 61) and after two years (n = 24) of treatment. Lumbar spine BMD standard deviation scores (SDS) were compared according to chronological age (CA) and bone age (BA) for the whole group, as well as for the group A, treated with leuprolide-acetate (n = 40), and the group B, treated with triptorelin (n = 21).
RESULTS
All subjects showed significant increment in BMD during treatment (P < 0.05). Lumbar spine BMD SDS for CA and BA showed no significant changes before and during treatment. Group A and group B, within each group, showed no significant changes in lumbar spine BMD SDS for CA and BA during treatment.
CONCLUSION
Our study suggests that lumbar spine BMD was not impaired in girls treated with GnRHa for CPP and both leuprolide-acetate and triptorelin showed comparable effects on lumbar spine BMD during treatment.

Keyword

Puberty, precocious; Bone density; Gonadotropin releasing hormone agonist; Leuprolide; Triptorelin

MeSH Terms

Absorptiometry, Photon
Bone Density
Female
Gonadotropin-Releasing Hormone
Humans
Leuprolide
Piperazines
Puberty, Precocious
Spine
Triptorelin Pamoate
Gonadotropin-Releasing Hormone
Leuprolide
Piperazines
Triptorelin Pamoate