J Korean Neuropsychiatr Assoc.  2011 Sep;50(5):368-374.

Comparison of the Subjective Quality of Life in Four Groups of Antipsychotics by Risk of Weight Gain in Patients with Schizophrenia

• Kim KH
• Kang SH
• Kang GY
• Lee KH
• Kim KK
• Soh M
• Ahn KJ
• Lee JI

Abstract

OBJECTIVES
The aim of this cross-sectional study was to compare the subjective quality of life in the four groups of antipsychotics according to the risk of weight gain in patients with schizophrenia.
METHODS
One hundred and thirty-two patients with schizophrenia that had taken the same antipsychotics for more than 1 year were enrolled in the analyses. Anti-psychotic agents were classified by the risk of weight gain into four groups : serious, common, not unusual, and unusual. The quality of life was measured with the Schizophrenia Quality of Life Scale Korean version, 4th Revision (SQLS-R4K). We analyzed the correlation between the total score of SQLS-R4K and clinical variables.
RESULTS
The SQLS-R4K score was significantly different in the four anti-psychotic groups (F=5.200, p=0.002). Gender, type of anti-psychotics (typical, atypical), duration of treatment with current antipsychotics, duration of illness, and Body Mass Index were not significantly correlated with the SQLS-R4K score.
CONCLUSION
The subjective quality of life was different according to the risk of weight gain groups of anti-psychotic agents.

Keyword

Schizophrenia; Quality of life; Antipsychotics; Weight gain risk

MeSH Terms

Antipsychotic Agents
Body Mass Index
Cross-Sectional Studies
Humans
Quality of Life
Schizophrenia
Weight Gain
Antipsychotic Agents