Korean J Psychopharmacol.  2006 Sep;17(5):423-428.

Association Study of -2548A/G Polymorphism of Leptin Gene with Antipsychotics-Induced Weight Gain

• Ryu S
• Jang WS
• Cho EY
• Kim SK
• Lee D
• Hong KS

Abstract

OBJECTIVES
Leptin, the product of ob gene, is secreted by adipocytes and signals the size of peripheral fat stores to the brain. Several evidences indicate that a polymorphism in the promoter region (-2548A/G) of leptin gene is associated with antipsychotics-induced weight gain. This study aims at investigating the association between the -2548A/G polymorphism of leptin gene and antipsychotics-induced weight gain in Korean schizophrenia patients.
METHODS
Seventy one patients with schizophrenia were recruited. All of the subjects were antipsychotics-naive or free of antipsychotic drugs for the previous 3 months. Genotyping was done for the -2548A/G polymorphism of leptin gene. Body mass index (BMI) was measured at baseline, after 4 weeks and after 8 weeks of antipsychotic drug treatment. The subjects were grouped on the basis of the presence or absence of the G allele (AA vs. AG/GG) and two-sided t tests for independent samples was used to analyze the relationship between two genotype groups and BMI change. And a chi-square analysis was conducted to test the association between the allele type and BMI change.
RESULTS
We could not find any association between the -2548A/G polymorphism of leptin gene and antipsychotics-induced weight gain.
CONCLUSION
Our data do not support the involvement of the -2548A/G polymorphism of leptin gene in antipsychotics-induced weight gain in the acute treatment phase.

Keyword

Antipsychotics; Weight gain; Leptin gene; Polymorphism; Association study

MeSH Terms

Adipocytes
Alleles
Antipsychotic Agents
Body Mass Index
Brain
Genotype
Humans
Leptin*
Promoter Regions, Genetic
Schizophrenia
Weight Gain*
Antipsychotic Agents
Leptin