Korean J Med.  2017 Apr;92(2):213-218. 10.3904/kjm.2017.92.2.213.

Improved Gastrointestinal Involvement in Systemic Sclerosis after Immunoglobulin Treatment

Affiliations
  • 1Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea. healthyra@schmc.ac.kr
  • 2Department of Radiology, Soonchunhyang University College of Medicine, Seoul, Korea.

Abstract

Systemic sclerosis is an intractable clinical subset characterized by diffuse fibrosis, vasculopathy, and immune abnormalities. Diffuse cutaneous systemic sclerosis has a variety of symptoms depending on the internal organs involved, such as the lungs, heart, kidneys, and gastrointestinal system. Gastrointestinal involvement is frequent and one of the major cause of morbidity and mortality. There is no sustained, effective therapy for treating the active gastrointestinal involvement of systemic sclerosis. Although immunoglobulin is commonly used in the treatment of other autoimmune diseases, its effects in the treatment of the gastrointestinal involvement in systemic sclerosis are unclear. Here, we report a patient with a severe cough caused by uncontrolled gastrointestinal involvement in diffuse cutaneous systemic sclerosis treated with immunoglobulin.

Keyword

Systemic sclerosis; Gastrointestinal involvement; Immunoglobulin

MeSH Terms

Autoimmune Diseases
Cough
Fibrosis
Heart
Humans
Immunoglobulins*
Kidney
Lung
Mortality
Scleroderma, Diffuse
Scleroderma, Systemic*
Immunoglobulins
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