Int Neurourol J.  2015 Mar;19(1):34-38. 10.5213/inj.2015.19.1.34.

Loss of Caveolin 1 is Associated With the Expression of Aquaporin 1 and Bladder Dysfunction in Mice

• Jung S
• Kim SO
• Cho KA
• Song SH
• Kang TW
• Park K
• Kwon D

• KMID: 2380824
• DOI: http://doi.org/10.5213/inj.2015.19.1.34

Abstract

PURPOSE
It is suggested that caveolin and aquaporin might be closely associated with bladder signal activity. We investigated the effect of the deletion of caveolin 1, using caveolin 1 knockout mice, on the expression of aquaporin 1 in order to identify their relation in the urothelium of the urinary bladder.
METHODS
The cellular localization and expressions of aquaporin 1 and caveolin 1, in the wild type and caveolin 1 knockout mice urinary bladder, were examined by Western blot and immunofluorescence techniques.
RESULTS
Aquaporin 1 and caveolin 1 were coexpressed in the arterioles, venules, and capillaries of the suburothelial layer in the wild type controls. Aquaporin 1 protein expression was significantly higher in the caveolin 1 knockout mice than in the wild type controls (P <0.05).
CONCLUSIONS
The results imply that aquaporin 1 and caveolin 1 may share a distinct relation with the bladder signal activity. This might play a specific role in bladder dysfunction.

Keyword

Aquaporin 1; Caveolin 1; Bladder

MeSH Terms

Animals
Aquaporin 1*
Arterioles
Blotting, Western
Capillaries
Caveolin 1*
Fluorescent Antibody Technique
Mice*
Mice, Knockout
Urinary Bladder*
Urothelium
Venules
Aquaporin 1
Caveolin 1