Epidemiol Health.  2011;33:e2011009.

Factors Associated with Insulin Resistance in a Middle-Aged Non-Obese Rural Population: The Chungju Metabolic Disease Cohort (CMC) Study

• Lim SY
• Ha HS
• Kwon HS
• Lee JH
• Yim HW
• Yoon KH
• Lee WC
• Son HY
• Park YM

Abstract

OBJECTIVES
We aimed to determine the characteristics affecting insulin resistance in non-obese middle-aged adults in a rural community.
METHODS
A total of 1,270 non-diabetic adults aged between 40 and 64 years old with body mass index (BMI) less than 25 kg/m2 were analyzed. Subjects with insulin resistance were defined as those who had the highest quartile value of the homeostasis model assessment of insulin resistance (HOMA-IR) in a non-diabetic population.
RESULTS
A total of 217 subjects (20.6%) had insulin resistance. Prevalence of metabolic syndrome was significantly higher in insulin-resistant subjects in both men (29.3% vs. 10.3%) and women (34.1% vs. 15.6%). Among metabolic syndrome components, elevated waist circumference and elevated triglyceride were higher in insulin-resistant subjects in both genders. After being controlled for socioeconomic status and lifestyle related covariates, the association between insulin resistance and BMI was statistically significant in the category of 23.0-24.9 kg/m2 in men (adjusted OR, 4.63; 95% confidence interval [95% CI], 1.77-12.15) using the category of 18.5-20.9 kg/m2 as a reference. In addition, the association between insulin resistance and abdominal obesity was statistically significant only for men (adjusted OR, 2.57; 95% CI, 1.29-5.11).
CONCLUSION
Insulin resistance appears to be highly associated with high BMI and abdominal obesity, even in non-obese, non-diabetic middle-aged men.

Keyword

Abdominal obesity; BMI; Insulin resistance

MeSH Terms

Adult
Aged
Body Mass Index
Cohort Studies
Female
Homeostasis
Humans
Insulin
Insulin Resistance
Life Style
Male
Metabolic Diseases
Obesity, Abdominal
Prevalence
Rural Population
Social Class
Waist Circumference
Insulin