J Bone Metab.  2017 May;24(2):83-89. 10.11005/jbm.2017.24.2.83.

Sarcopenia: Neurological Point of View

Affiliations
  • 1Department of Neurology, College of Medicine, Kyung Hee University, Seoul, Korea. hsyoon96@khu.ac.kr

Abstract

Sarcopenia is an age-related geriatric syndrome which is characterized by the gradual loss of muscle mass, muscle strength, and muscle quality. There are a lot of neurologic insults on sarcopenia at various levels from the brain to the neuromuscular junctions (NMJs) to generate a volitional task. Dopaminergic downregulation, inadequate motor programming and motor coordination impairment lead to decline of supraspinal drive. Motor unit reorganization and inflammatory changes in motor neuron decrease conduction velocity and amplitude of compound muscle action potential. Furthermore, NMJ remodeling and age related neurophysiological alterations may contribute to neuromuscular impairment. Sarcopenia is an age-associated, lifelong process which links to multiple etiological factors. Although not all the causes are completely understood, we suggest that compromised nervous system function may be one of the important contributors to the sarcopenia.

Keyword

Aging; Motor neurons; Nervous system; Neuromuscular junction; Sarcopenia

MeSH Terms

Action Potentials
Aging
Ataxia
Brain
Down-Regulation
Motor Neurons
Muscle Strength
Nervous System
Neuromuscular Junction
Sarcopenia*
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