Gut Liver.
2015 Nov;9(6):776-783. 10.5009/gnl14297.
Comparison of the Effects of Telbivudine and Entecavir Treatment on Estimated Glomerular Filtration Rate in Patients with Chronic Hepatitis B
- Affiliations
-
- 1Department of Internal Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.
- 2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. AHNSH@yuhs.ac
- 3Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
- 4Liver Cancer Special Clinic, Yonsei University College of Medicine, Seoul, Korea.
- 5Liver Cirrhosis Clinical Research Center, Seoul, Korea.
- 6Department of Biostatistics, Yonsei University College of Medicine, Seoul, Korea.
- 7Brain Korea 21 Project for Medical Science, Seoul, Korea.
- KMID: 2377936
- DOI: http://doi.org/10.5009/gnl14297
Abstract
- BACKGROUND/AIMS
The aim of this study was to evaluate the estimated glomerular filtration rate (eGFR) during telbivudine (LdT) versus entecavir (ETV) treatment in chronic hepatitis B (CHB) patients with underlying comorbidities such as diabetes mellitus (DM), hypertension, and cirrhosis.
METHODS
From 2010 to 2012, 116 CHB patients treated with LdT and 578 treated with ETV were compared in this real-practice cohort. The mean changes in eGFR (Modification of Diet in Renal Disease [MDRD] formula) from baseline to months 6, 12, and 18 were analyzed using a linear mixed model.
RESULTS
In LdT-treated patients, the mean eGFR increased by 7.6% at month 18 compared with the eGFR at baseline (MDRD formula in mL/min/1.73 m2). However, in ETV-treated patients, the mean eGFR decreased by 4.1% at month 18 compared with the eGFR at baseline. In the LdT-treated patients with DM, hypertension, cirrhosis or low eGFR <90 mL/min/1.73 m2, the mean eGFR showed a steady improvement, whereas the mean eGFR was reduced in the same subgroups of ETV-treated patients.
CONCLUSIONS
The eGFR gradually increased over time during LdT treatment, especially in patients with mild abnormal eGFR at baseline, and in those with DM, hypertension, and cirrhosis, whereas a reduction in eGFR was seen with ETV treatment.
MeSH Terms
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Adult
Antiviral Agents/*administration & dosage
Diabetes Complications
Diabetes Mellitus
Drug Administration Schedule
Female
Fibrosis/complications
Glomerular Filtration Rate/*drug effects
Guanine/administration & dosage/*analogs & derivatives
Hepatitis B, Chronic/complications/*drug therapy/physiopathology
Humans
Hypertension/complications
Linear Models
Male
Middle Aged
Thymidine/administration & dosage/*analogs & derivatives
Time Factors
Treatment Outcome
Antiviral Agents
Guanine
Thymidine
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