Korean J Otorhinolaryngol-Head Neck Surg.  2017 Apr;60(4):153-157. 10.3342/kjorl-hns.2017.00129.

Tissue-Engineered Tracheal Regeneration: Current Status

• Shin YS

• KMID: 2377568
• DOI: http://doi.org/10.3342/kjorl-hns.2017.00129

Abstract

Tracheal regeneration is very challenging clinical demand because the trachea is not a simple windpipe, but a multilayered, complex structure. The tissue-engineering technique is widely accepted as promising strategy in tracheal regeneration. For successful regeneration, a substitute for trachea should provide not only appropriate laterally rigidity and longitudinally flexibility for sustaining the luminal shape of the trachea, but also favorable environment for respiratory ciliated epithelium, smooth muscle and blood vessel cells to regenerate. To date, a variety of materials such as polyglycolic acid, poly (lactic-co-glycolic acid), polycarprolactone, nanocomposite polymers and many naturally-derived scaffolds have been investigated. With these investigations, several clinical attempt of tracheal replacement with artificial trachea have been tried, but clinical outcome has not been quite satisfying. This article reviews the regeneration of C-shaped cartilage, respiratory ciliated epithelium and neovascularization of artificial trachea, together with the difficulties, plausible options and future perspectives.

Keyword

Regenerative medicine; Scaffold; Stem cells; Tissue engineering; Trachea

MeSH Terms

Blood Vessels
Cartilage
Epithelium
Muscle, Smooth
Nanocomposites
Phenobarbital
Pliability
Polyglycolic Acid
Polymers
Regeneration*
Regenerative Medicine
Stem Cells
Tissue Engineering
Trachea
Phenobarbital
Polyglycolic Acid
Polymers