J Korean Radiol Soc.  1998 Jul;39(1):137-142.

Plugging the Biopsy Tract in Rabbit Liver: Gelfoam, Fibrin Sealant and NBCA

• Kwak BK
• Jung KH
• Choi CH
• Yoon HR
• Park YO
• Lee CJ
• Kim HH
• Chang HJ
• Shim HJ

Abstract

PURPOSE: To evaluate the effect of plugging the biopsy tract in rabbit liver and the pathologic changes caused by plugging materials.
MATERIALS AND METHODS
Thirty-two New Zealand White rabbits were divided into four groups(eight rabbits in each) and compared with one another. They were labeled group A(control), B(gelfoam),C(fibrin sealant) or D(NBCA). The liver was exposed and biopsied with an 18G disposible biopsy gun. The inner Tru-cut needle was withdrawn and plugging was undertaken through the outer cannula of the biopsy gun. Bleeding times of each material were compared. The rabbits were sacrificed and pathologically evaluated for 17 days.
RESULTS
Mean bleeding times were 46.7+/-34.5 sec in group A, 42.9+/-54.7 sec in group B, 12.6+/-15.0 sec in group C, and 0 sec in group D. In groups C and D, these results were statistically significant(p<0.01). Pathologically, fibrin sealant was lowest in foreign body reaction and fibrosis. NBCA was effective for the prevention of hemorrhage.
CONCLUSION
NBCA and fibrin sealant effectively plug the biopsy tract through the outer cannula of an18 G biopsy gun.

Keyword

Animals, Liver, biopsy; Biopsies, complications; Biopsies, technology

MeSH Terms

Biopsy*
Bleeding Time
Catheters
Fibrin Tissue Adhesive*
Fibrin*
Fibrosis
Foreign-Body Reaction
Gelatin Sponge, Absorbable*
Hemorrhage
Liver*
Needles
Rabbits
Fibrin
Fibrin Tissue Adhesive