J Lab Med Qual Assur.  2017 Mar;39(1):42-46. 10.15263/jlmqa.2017.39.1.42.

Platelet Distribution Width from Two Automated Hematology Analysers: A Correlation Analysis

• Lee E
• Kim HS
• Kang HJ
• Kim M
• Lee YK

• KMID: 2376751
• DOI: http://doi.org/10.15263/jlmqa.2017.39.1.42

Abstract

Platelet distribution width (PDW) is an index for platelet size variation. In this study, we analysed the correlation between PDW values obtained using two different hematology analysers that employ different measurement methods. Complete blood cell parameters including PDW for 153 healthy individuals were measured using both, ADVIA 2120i (Simens AG, Germany) and XN-3000 (Sysmex, Japan). The PDW values measured using the two hematology analysers showed a moderate correlation (r=0.661, P<0.001), while the hemoglobin, mean corpuscular volume, red blood cell distribution width values and white blood cell and platelet counts showed strong correlations (r >0.900, P<0.001). PDW obtained using XN-3000 showed a strong correlation with mean platelet volume, whereas PDW obtained using ADVIA 2120i did not. The reference values in this group were 40.0%-64.2% in ADVIA 2120i and 9.0-16.0 fL in XN-3000. In conclusion, PDW values obtained using ADVIA 2120i and XN-3000 are not interchangeable. In laboratories equipped with more than one hematology analyser, a particular analyser should be used consistently for monitoring a particular patient.

Keyword

Platelet distribution width; ADVIA 2120i; XN-3000

MeSH Terms

Blood Cells
Blood Platelets*
Erythrocyte Indices
Erythrocytes
Hematology*
Humans
Leukocytes
Mean Platelet Volume
Platelet Count
Reference Values