Blood Res.  2023 Dec;58(4):187-193. 10.5045/br.2023.2023156.

Correlation between red blood cell distribution width/platelet count and prognosis of newly diagnosed diffuse large B-cell lymphoma

• Liu X
• Bai Y
• Liu Y
• Li W
• Cui Y
• Xu J
• Xiao X
• Niu X
• Sun K

• KMID: 2550196
• DOI: http://doi.org/10.5045/br.2023.2023156

Abstract

Background
Red blood cell distribution width/platelet count ratio (RPR) is a reliable prognostic assessment indicator for numerous diseases. However, no studies to date have examined the relationship between RPR and the prognosis of diffuse large B-cell lymphoma (DLBCL). Therefore, this study aimed to investigate the correlation between RPR and the clinical characteristics and prognosis of patients with diffuse large B-cell lymphoma.
Methods
We retrospectively studied 143 patients with newly diagnosed DLBCL and used the median value as the RPR threshold. We also investigated the correlation of pretreatment RPR level with clinical characteristics and its impact on DLBCL prognosis.
Results
Using the median value as the cut-off, patients with DLBCL were divided into a low RPR group (＜0.0549) and a high RPR group (≥0.0549). Patients in the high RPR group were older, had a later Ann Arbor stage, were prone to bone marrow invasion, and had a higher National Comprehensive Cancer Network International Prognostic Index score (P ＜ 0.05). A survival analysis showed that progression-free survival (PFS) (P =0.003) and overall survival (OS) (P ＜0.0001) were significantly shorter in the high versus low RPR group. A multifactorial Cox analysis showed that bone marrow invasion and elevated lactate dehydrogenase (LDH) were separate risk factors for PFS (P ＜0.05), while an RPR ≥0.0549 and elevated LDH were separate risk factors for OS (P ＜0.05).
Conclusion
A high RPR (≥0.0549) in patients with newly diagnosed DLBCL is an independent risk factor for a poor prognosis.

Keyword

Red blood cell distribution width; Platelet count; Diffuse large B-cell lymphoma; Prognosis

Figure

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  Fig. 1 Kaplan-Meier curves of overall survival (OS) and progression-free survival (PFS). (A, B) Kaplan-Meier curves of PFS and OS in all patients. (C, D) Kaplan-Meier curves for PFS and OS according to red blood cell distribution width/platelet count (RPR). (E, F) Kaplan-Meier curves of PFS and OS were plotted according to RPR in the germinal center B-cell (GCB) group. (G, H) Kaplan-Meier curves of PFS and OS were plotted according to the RPR in the non-GCB group. (I, J) Kaplan-Meier curves of PFS and OS were plotted according to RPR in the group aged ≤60 years. (K, L) Kaplan-Meier curves of PFS and OS were plotted according to RPR in the group aged >60 years.

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