Tuberc Respir Dis.  2017 Apr;80(2):143-152. 10.4046/trd.2017.80.2.143.

Current Status of Fluoroquinolone Use for Treatment of Tuberculosis in a Tertiary Care Hospital in Korea

• Kang BH
• Jo KW
• Shim TS

• KMID: 2375983
• DOI: http://doi.org/10.4046/trd.2017.80.2.143

Abstract

BACKGROUND
Fluoroquinolones are considered important substitutes for the treatment of tuberculosis. This study investigates the current status of fluoroquinolone for the treatment of tuberculosis.
METHODS
In 2009, a retrospective analysis was performed at one tertiary referral center for 953 patients diagnosed with tuberculosis.
RESULTS
A total of 226 patients (23.6%), who received fluoroquinolone at any time during treatment for tuberculosis, were enrolled in this study. The most common reasons for fluoroquinolone use were adverse events due to other anti-tuberculosis drugs (52.7%), drug resistance (23.5%), and underlying diseases (16.8%). Moxifloxacin (54.0%, 122/226) was the most commonly administered fluoroquinolone, followed by levofloxacin (36.3%, 82/226) and ofloxacin (9.7%, 22/226). The frequency of total adverse events from fluoroquinolone-containing anti-tuberculosis medication was 22.6%, whereas fluoroquinolone-related adverse events were estimated to be 2.2% (5/226). The most common fluoroquinolone-related adverse events were gastrointestinal problems (3.5%, 8/226). There were no significant differences in the treatment success rate between the fluoroquinolone and fluoroquinolone-naïve groups (78.3% vs. 78.4%, respectively).
CONCLUSION
At our institution, fluoroquinolones are commonly used for the treatment of both multidrug-resistant tuberculosis and susceptible tuberculosis, especially as a substitute for adverse event-related drugs. Considering the low adverse event rates and the comparable treatment success rates, fluoroquinolones seem to be an invaluable drug for the treatment of tuberculosis.

Keyword

Fluoroquinolones; Tuberculosis; Therapeutics; Drug Resistance

MeSH Terms

Drug Resistance
Fluoroquinolones
Humans
Korea*
Levofloxacin
Ofloxacin
Retrospective Studies
Tertiary Care Centers
Tertiary Healthcare*
Tuberculosis*
Tuberculosis, Multidrug-Resistant
Fluoroquinolones
Ofloxacin

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