Korean J Endocr Surg.  2012 Mar;12(1):16-20. 10.0000/kjes.2012.12.1.16.

Association of BRAF(V600E) Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma

• Choi HS
• Kim KM
• Park JB
• Bae KS
• Kang SJ

• KMID: 2375396
• DOI: http://doi.org/10.0000/kjes.2012.12.1.16

Abstract

PURPOSE
This study evaluated the association of the BRAF(V600E) mutation with known prognostic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma.
METHODS
Subjects included 169 patients who received thyroidectomy at Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from February 2010 to October 2011.
RESULTS
Of the total patients who received thyroidectomy, there were 128 cases (75,7%) of BRAF(V600E) mutation. Neither age nor sex were associated with the BRAF(V600E) mutation. Tumor size, shape, margin, extrathyroidal extension, central node metastasis and lateral node metastasis were found not to be associated with the BRAF(V600E) mutation. Tumor calcification, echogenicity and vascularity were also not associated with the mutation.
CONCLUSION
As debate remains about the association between the BRAF(V600E) mutation and clincopathologic factors and ultrasonographic characteristics in cases of papillary thyroid carcinoma, further study is needed.

Keyword

BRAFV600E mutation; Clinicopathologic factors; Ultrasonographic characteristics

MeSH Terms

Diagnosis
Gangwon-do
Humans
Neoplasm Metastasis
Thyroid Gland*
Thyroid Neoplasms*
Thyroidectomy