Int J Thyroidol.  2016 May;9(1):29-34. 10.11106/ijt.2016.9.1.29.

Clinicopathological Implications of the BRAF(V600E) Mutation in PTC with Concurrent Hashimoto Thyroiditis

• Park S
• Kim WG
• Kim M
• Kwon H
• Choi YM
• Jeon MJ
• Kim TY
• Shong YK
• Kim WB

• KMID: 2164913
• DOI: http://doi.org/10.11106/ijt.2016.9.1.29

Abstract

BACKGROUND AND OBJECTIVES
The relationship between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) is still controversial. Some studies suggested that molecular basis of the association between HT and PTC. BRAF(V600E) mutation is the most common genetic alteration founded in PTC. This study was to determine a role of BRAF(V600E) mutation in PTC with concurrent HT and their association with other clinicopathological factors.
MATERIALS AND METHODS
We enrolled 452 patients who underwent thyroid surgery between 2009 and 2012 for classical PTC. The status of BRAF(V600E) mutation was evaluated by direct sequencing. HT was defined as presence of lymphocytic thyroiditis in pathology or positive serum anti-thyroid peroxidase antibody.
RESULTS
Total 139 patients (30%) with PTC had coexistence HT. HT was significantly associated female (p=0.006), and younger age (p=0.045). BRAF(V600E) mutation was confirmed in 264 patients (58%). The frequency of BRAF(V600E) mutation was significantly lower in PTC with coexistence HT (48.2%) compared by PTC without HT (62.9%, p=0.004). However, there was no significant difference in clinicopathological feature of PTC according to the presence of HT in patients with BRAF(V600E) mutated PTC. BRAF(V600E) mutation was less frequent in PTC with coexistence HT.
CONCLUSION
These findings suggested that HT and BRAF(V600E) mutation might be independent factors in development and progression of PTC.

Keyword

Hashimoto thyroiditis; Papillary thyroid carcinoma; BRAF(V600E) mutation

MeSH Terms

Female
Hashimoto Disease*
Humans
Pathology
Peroxidase
Thyroid Gland
Thyroid Neoplasms
Thyroiditis, Autoimmune
Peroxidase

Figure

• 

  Fig. 1. Frequency of BRAF V600E mutation in classical PTC according to the coexistence of HT.

Reference

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