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Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma

Jeon MJ, Kim WG, Kim TY, Shong YK, Kim WB

Active surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC) has been accepted worldwide as safe and effective. Despite the growing acceptance of AS in the management of low-risk PTMCs, there...
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Gender-Dependent Reference Range of Serum Calcitonin Levels in Healthy Korean Adults

Song E, Jeon MJ, Yoo HJ, Bae SJ, Kim TY, Kim WB, Shong YK, Kim HK, Kim WG

Background: Serum calcitonin measurement contains various clinical and methodological aspects. Its reference level is wide and unclear despite sensitive calcitonin kits are available. This study aimed to identify the specific...
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Assessing the diagnostic performance of thyroid biopsy with recommendations for appropriate interpretation

Ha SM, Baek JH, Na DG, Jung CK, Suh CH, Shong YK, Sung TY, Song DE, Lee JH

Purpose: The diagnostic performance of thyroid biopsy is influenced by several factors, including differences in the Bethesda categorization for malignancy, the inclusion or exclusion of non-diagnostic results, the definition used...
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Clinical Implication of World Health Organization Classification in Patients with Follicular Thyroid Carcinoma in South Korea: A Multicenter Cohort Study

Jin M, Kim ES, Kim BH, Kim HK, Yi HS, Jeon MJ, Kim TY, Kang HC, Kim WB, Shong YK, Kim M, Kim WG

Background: The study aimed to compare the prognostic value of the 4th edition of World Health Organization classification (WHO-2017) with the previous WHO classification (WHO-2004) for follicular thyroid carcinoma (FTC). Methods:...
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Clinical Outcomes of N1b Papillary Thyroid Cancer Patients Treated with Two Different Doses of Radioiodine Ablation Therapy

Jin M, Ahn J, Lee YM, Sung TY, Kim WG, Kim TY, Ryu JS, Kim WB, Shong YK, Jeon MJ

Background: The optimal dose of radioactive iodine (RAI) therapy for N1b papillary thyroid carcinoma (PTC) is controversial. We evaluated the clinical outcome of N1b PTC patients treated with either 100...
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Vandetanib for the Management of Advanced Medullary Thyroid Cancer: A Real-World Multicenter Experience

Kim M, Yoon JH, Ahn J, Jeon MJ, Kim HK, Lim DJ, Kang HC, Kim IJ, Shong YK, Kim TY, Kim BH

Background: Vandetanib is the most widely used tyrosine kinase inhibitor for the treatment of patients with advanced medullary thyroid cancer (MTC). However, only limited data regarding its use outside clinical...
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Association between urinary sodium levels and iodine status in Korea

Ahn J, Lee JH, Lee J, Baek JY, Song E, Oh HS, Kim M, Park S, Jeon MJ, Kim TY, Kim WB, Shong YK, Kim WG

Background/Aims: To evaluate the association between the urinary sodium concentration and iodine status in different age groups in Korea. Methods: This nationwide, population-based, cross-sectional study used data from the Korean National...
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Modification of the Tumor-Node-Metastasis Staging System for Differentiated Thyroid Carcinoma by Considering Extra-Thyroidal Extension and Lateral Cervical Lymph Node Metastasis

Kim M, Kim WG, Jeon MJ, Kim HK, Yi HS, Kim ES, Kim BH, Kim WB, Shong YK, Kang HC, Kim TY

BACKGROUND: Concerns have arisen about the classification of extra-thyroidal extension (ETE) and lateral cervical lymph node metastasis (N1b) in the 8th edition of the tumor-node-metastasis staging system (TNM-8). This study...
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Quality of Life in Patients with Papillary Thyroid Microcarcinoma According to Treatment: Total Thyroidectomy with or without Radioactive Iodine Ablation

Ahn J, Jeon MJ, Song E, Kim TY, Kim WB, Shong YK, Kim WG

BACKGROUND: Recently, there has been some controversy regarding the role of radioactive iodine (RAI) ablation in the treatment of low-risk differentiated thyroid carcinoma (DTC), especially papillary thyroid microcarcinoma (PTMC). This...
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Unmet Clinical Needs in the Treatment of Patients with Thyroid Cancer

Kim WB, Jeon MJ, Kim WG, Kim TY, Shong YK

The increased incidence of thyroid cancer is a worldwide phenomenon; however, the issue of overdiagnosis has been most prominent in South Korea. The age-standardized mortality rate of thyroid cancer in...
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Clinical Outcomes after Early and Delayed Radioiodine Remnant Ablation in Patients with Low-Risk Papillary Thyroid Carcinoma: Propensity Score Matching Analysis

Ahn J, Jin M, Song E, Jeon MJ, Kim TY, Ryu JS, Kim WB, Shong YK, Han JM, Kim WG

Background: The clinical outcomes of delayed radioiodine remnant ablation (RRA) therapy in patients with low-risk papillary thyroid carcinoma (PTC) are unclear. We aimed to evaluate the clinical impact of the...
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Expression of NF2 Modulates the Progression of BRAFV600E Mutated Thyroid Cancer Cells

You MH, Jeon MJ, Kim TY, Kim WB, Shong YK, Kim WG

BACKGROUND: We previously reported the frequent neurofibromatosis 2 (NF2) gene mutations in anaplastic thyroid cancers in association with the BRAF V600E mutation. We aimed to investigate the role of NF2 in...
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Comparison of Thyroid Hormones in Euthyroid Athyreotic Patients Treated with Levothyroxine and Euthyroid Healthy Subjects

Jeon MJ, Lee SH, Lee JJ, Han MK, Kim HK, Kim WG, Kim TY, Kim WB, Shong YK, Ryu JS

BACKGROUND AND OBJECTIVES: Levothyroxine (L-T4) monotherapy to normalize TSH level might be not sufficient to restore serum free triiodothyronine (fT3) levels in hypothyroid patients. This study aimed to compare the...
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Ethanol ablation as a treatment strategy for benign cystic thyroid nodules: a comparison of the ethanol retention and aspiration techniques

Park HS, Yim Y, Baek JH, Choi YJ, Shong YK, Lee JH

PURPOSE: We compared the efficacy and safety of two ethanol ablation techniques-ethanol aspiration and ethanol retention-for benign cystic thyroid nodules. METHODS: From October 2008 to September 2013, 113 patients who were...
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A Case of Severe Pneumocystis Pneumonia in a Thyroid Cancer Patient Receiving Lenvatinib

Jin MH, Kim WG, Kim TY, Kim WB, Shong YK, Jeon MJ

Lenvatinib is a multitargeted tyrosine kinase inhibitor approved for use in patients with iodine-131–refractory thyroid cancer. The common adverse events of lenvatinib include hypertension, proteinuria, fatigue, and diarrhea. To date,...
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Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of the BRAF(V600E) Mutation in Thyroid Neoplasm

Oh HS, Kwon H, Park S, Kim M, Jeon MJ, Kim TY, Shong YK, Kim WB, Choi J, Kim WG, Song DE

BACKGROUND: The BRAF V600E mutation is the most common genetic alteration identified in papillary thyroid carcinoma (PTC). Because of its costs effectiveness and sensitivity, direct Sanger sequencing has several limitations. The...
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Efficacy and Safety of Radiofrequency Ablation for Benign Thyroid Nodules: A Prospective Multicenter Study

Jung SL, Baek JH, Lee JH, Shong YK, Sung JY, Kim KS, Lee D, Kim JH, Baek SM, Sim JS, Na DG

OBJECTIVE: To assess the efficacy and safety of thyroid radiofrequency (RF) ablation for benign thyroid nodules by trained radiologists according to a unified protocol in a multi-center study. MATERIALS AND METHODS:...
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Clinical Outcomes of Differentiated Thyroid Cancer Patients with Local Recurrence or Distant Metastasis Detected in Old Age

Han JM, Bae JC, Kim HI, Kwon S, Jeon MJ, Kim WG, Kim TY, Shong YK, Kim WB

BACKGROUND: Differentiated thyroid carcinoma (DTC) shows a very good prognosis, but older patients have a higher recurrence rate and those show poor prognosis than younger patients. The aim of this...
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Clinical Guidelines for the Management of Adrenal Incidentaloma

Lee JM, Kim MK, Ko SH, Koh JM, Kim BY, Kim SW, Kim SK, Kim HJ, Ryu OH, Park J, Lim JS, Kim SY, Shong YK, Yoo SJ, Korean Endocrine Society, Committee for Clinical Practice Guidelines

An adrenal incidentaloma is an adrenal mass found in an imaging study performed for other reasons unrelated to adrenal disease and often accompanied by obesity, diabetes, or hypertension. The prevalence...
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Myxoid and Sarcomatoid Variants of Adrenocortical Carcinoma: Analysis of Rare Variants in Single Tertiary Care Center

Sung TY, Choi YM, Kim WG, Lee YM, Kim TY, Shong YK, Kim WB, Song DE

The aim of this study is to describe rare variants of adrenocortical carcinoma (ACC) and to compare the prognosis with that of conventional ACC. We retrospectively reviewed 8 cases of...
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