Korean J Pathol.
2013 Jun;47(3):293-298.
A Case of Multifocal Papillary Thyroid Carcinoma Consisting of One Encapsulated Follicular Variant with BRAF K601E Mutation and Three Conventional Types with BRAF V600E Mutation
- Affiliations
-
- 1Department of Pathology, Konkuk University School of Medicine, Seoul, Korea. tshwang@kuh.ac.kr
- 2Department of Pathology, Konkuk University Medical Center, Seoul, Korea.
Abstract
- Multifocal papillary thyroid carcinoma (mPTC) comprises about 20-30% of PTC. In mPTC, individual tumor foci can be identical or frequently composed of different histological types including follicular, solid, tall-cell or conventional patterns. We report a case of mPTC consisting of one encapsulated follicular variant of papillary thyroid carcinoma (FVPTC) and three conventional PTCs in a 44-year-old woman. This case genetically demonstrates unique features including the simultaneous presence of the BRAF V600E (T1799A) mutation and the BRAF K601E (A1801G) mutation in conventional PTC and FVPTC, respectively.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Prevalence of BRAF(V600E) Mutation in Follicular Variant of Papillary Thyroid Carcinoma and Non-Invasive Follicular Tumor with Papillary-Like Nuclear Features (NIFTP) in a BRAF(V600E) Prevalent Area
- Association of BRAF(V600E) Mutation with Poor Clinical Prognostic Factors and Ultrasonographic Findings in Cases of Papillary Thyroid Carcinoma
- Clinical Implication of BRAF Mutation in Thyroid Cancer
- Expressions of miRNAs in Papillary Thyroid Carcinoma and Their Associations with the BRAFV600EMutation and Clinicopathological Features.
- Relation between RASSF1A Methylation and BRAF Mutation in Thyroid Tumor
